(7-methoxybenzofuran-3-yl)acetic acid | 79477-01-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (7-methoxybenzofuran-3-yl)acetic acid
• 英文别名: 7-methoxy-3-benzofuranacetic acid；(7-methoxy-1-benzofuran-3-yl)acetic acid；2-(7-Methoxy-1-benzofuran-3-yl)acetic acid
• CAS: 79477-01-3
• 化学式: C₁₁H₁₀O₄
• 分子量: 206.198
• InChiKey: YECIFNKYUBNXQR-UHFFFAOYSA-N

物化性质

• 沸点：
  369.3±27.0 °C(Predicted)
• 密度：
  1.306±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (7-methoxybenzofuran-3-yl)acetic acid 在 吡啶 、 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 N-(5-bromofuran-2-ylmethyl)-N-tert-butyl-2-(7-methoxybenzofuran-3-yl)acetamide
  参考文献：
  名称：

  Intramolecular Cyclization Reactions of 5-Halo- and 5-Nitro-Substituted Furans

  摘要：

  [GRAPHICS]Intramolecular cyclization reactions of 5-halo- and 5-nitro-substituted furanylamides were examined. The 2-alkoxy-5-bromofuran derivative 2 produced the rearranged dihydroquinone 6 (36%), a product from the rearrangement of the intermediate oxabicycle 3. The 5-halo substituted furoyl amide 18 was converted to the polyfunctional oxabicycle 20 in 82% yield and at a much faster rate than the unsubstituted furanyl system 17. The 5-nitro-substituted furfuryl amide 33b underwent an unusual isomerization-cyclization reaction under microwave conditions to provide 1,4-dihydro-2H-benzo[4,5]furo[2,3-c]pyridin-3-one 34.

  DOI：

  10.1021/ol035233k
• 作为产物：
  描述：

  7-Methoxybenzofuran-3-essigsaeureaethylester 在 水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (7-methoxybenzofuran-3-yl)acetic acid
  参考文献：
  名称：

  FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS

  摘要：

  本发明公开了以下式（I）的化合物或其药学上可接受的盐：其抑制由乙型肝炎病毒（HBV）编码的蛋白质或干扰乙型肝炎病毒的生命周期功能，并且还可用作抗病毒剂。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HBV感染的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HBV感染的方法。

  公开号：

  US20200095258A1

文献信息

• Imide intermediates for the preparation of analgesic and/or antagonist
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04751306A1

  公开（公告）日：1988-06-14

  Imide intermediates for the preparation of analgesic and/or antagonist octahydrobenzofuro[3,2-e]-isoquinolines and octahydro-4a,7-ethano- and ethenobenzofuro[3,2-e]isoquinolines and processes for their preparation are provided. These imides have a formula selected from the group consisting of: ##STR1##

  提供用于制备镇痛剂和/或拮抗剂八氢苯并噻吩[3,2-e]-异喹啉和八氢-4a,7-乙基-和乙烯基苯并噻吩[3,2-e]异喹啉的亚胺中间体及其制备方法。这些亚胺的化学式选自以下组合：##STR1##
• Benzene-condensed heterocyclic derivatives and their uses
  申请人：——

  公开号：US06323235B1

  公开（公告）日：2001-11-27

  Novel compounds having strong TXA2 receptor antagonist activities and PGI2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA2, are disclosed. The compound of the present invention is represented by the following formula (I). (wherein the meanings of the symbols in the formula are as described in the specification).

  本发明揭示了具有强烈TXA2受体拮抗活性和PGI2受体激动活性的新型化合物，可用于治疗和预防与TXA2相关的疾病。本发明的化合物由以下式(I)表示（其中式中符号的含义如说明书所述）。
• BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0751126A1

  公开（公告）日：1997-01-02

  Novel compounds having strong TXA2 receptor antagonist activities and PGI2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA2, are disclosed. The compound of the present invention is represented by the following formula (I). (wherein the meanings of the symbols in the formula are as described in the specification)

  本发明公开了具有很强的TXA2受体拮抗剂活性和PGI2受体激动剂活性的新型化合物，可有效治疗和预防与TXA2有关的疾病。本发明的化合物由下式（I）表示。 (其中式中符号的含义如说明书所述）
• Functionalized heterocycles as antiviral agents
  申请人：ENANTA PHARMACEUTICALS, INC

  公开号：US10865211B2

  公开（公告）日：2020-12-15

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物或其药学上可接受的盐类： 其可抑制乙型肝炎病毒（HBV）编码的蛋白质或干扰乙型肝炎病毒 HBV 生命周期的功能，还可用作抗病毒剂。本发明进一步涉及包含上述化合物的药物组合物，用于给受 HBV 感染的患者用药。本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者 HBV 感染的方法。
• 2,3,4,4a,5,6,7,7a-Octahydro-1H-benzofuro[3,2-e]isoquinoline: a new morphine fragment
  作者：Engelbert Ciganek

  DOI：10.1021/ja00410a065

  日期：1981.10