N-allylbut-3-en-1-amine | 80662-96-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-allylbut-3-en-1-amine
• 英文别名: N-2-propen-1-yl-3-buten-1-amine；(3-Butenyl)allylamine；N-prop-2-enylbut-3-en-1-amine
• CAS: 80662-96-0
• 化学式: C₇H₁₃N
• 分子量: 111.187
• InChiKey: DYSSMLMNWJFMLI-UHFFFAOYSA-N

物化性质

• 沸点：
  140.8±19.0 °C(Predicted)
• 密度：
  0.777±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-allylbut-3-en-1-amine 在 palladium diacetate 、 Grubbs catalyst first generation 、 Ti₂CO₃ 、 三苯基膦 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 25.0~95.0 ℃ 、101.33 kPa 条件下， 反应 3.0h， 生成 1-benzyl-3-[2-(3,6-dihydro-2H-pyridin-1-yl)-2-oxoethyl]-3-methylindol-2-one
  参考文献：
  名称：

  顺序和级联钯催化的环化-阴离子捕获-烯烃复分解

  摘要：

  钯催化的级联环化阴离子捕获的顺序或级联组合涉及烯烃复分解的二元和三元过程，可提供高收率的稠合和螺环体系，并报道了桥接的成环序列。

  DOI：

  10.1016/s0040-4039(99)00314-7
• 作为产物：
  描述：

  在 4-甲苯硫酚 、 potassium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 1.33h， 生成 N-allylbut-3-en-1-amine
  参考文献：
  名称：

  Effect of Added Salt on Ring-Closing Metathesis Catalyzed by a Water-Soluble Hoveyda–Grubbs Type Complex To Form N-Containing Heterocycles in Aqueous Media

  摘要：

  The efficiency of ring-closing metathesis catalyzed by a Hoveyda-Grubbs type catalyst in water can be enhanced by addition of a chloride salt under neutral conditions. UV-vis spectroscopic study showed that a characteristic band of the catalyst around 380 nm remained over 16 h in the presence of KCl, whereas the band distinctly decreased in the absence of KCl. The disappearance of the band is ascribed to a displacement of a chloride ligand by a water molecule or a hydroxide anion. The spectral changes can be related to the metathesis activity. The experimental results indicate that avoidance of the chloride ligand loss is important to maintain the metathesis activity in water.

  DOI：

  10.1021/om4005302

文献信息

• Synthesis of medium-sized aryl-fused nitrogenous heterocycles <i>via</i> sequential aryne aza-Claisen rearrangement/ring-closing metathesis
  作者：N. S. V. M. Rao Mangina、Ravinder Guduru、Galla V. Karunakar

  DOI：10.1039/c7ob03166a

  日期：——

  The reaction of arynes and secondary allylamines furnished ortho-allyl-substituted N-arylanilines via an aza-Claisen rearrangement. In this transformation, the sequential formation of C–C and C–N bonds occurred by involving two aryne molecules under metal-free reaction conditions to provide moderate to good yields of the products. The obtained ortho-allyl-substituted N-arylaniline derivatives were

  芳烃和仲烯丙胺的反应通过氮杂-克莱森重排提供邻-烯丙基取代的N-芳基苯胺。在这种转化过程中，通过在无金属反应条件下使两个芳烃分子参与进来，从而形成了C–C和C–N键的顺序形成，从而提供了中等至良好的收率。获得的邻烯丙基取代的N-芳基苯胺衍生物通过闭环复分解（RCM）进一步转化为芳基稠合的中等大小（7-9）含氮杂环分子，例如氮杂，氮杂和苯丙氨酸。
• Amine-directed intramolecular hydroacylation of alkenes and alkynes
  作者：Holly D. Bendorf、Kyle E. Ruhl、Andrew J. Shurer、Jennie B. Shaffer、Tess O. Duffin、Theresa L. LaBarte、Michelle L. Maddock、Oscar W. Wheeler

  DOI：10.1016/j.tetlet.2011.12.125

  日期：2012.3

  Medium-ring heterocycles are prepared via an amine-directed, rhodium(I)-catalyzed intramolecular hydroacylation. The presence of an allyl substituent on the amine accelerates the reaction and increases product yields.

  通过胺导向的铑（I）催化的分子内加氢酰化反应制备中环杂环。胺上烯丙基取代基的存在加速了反应并提高了产物产率。
• NOVEL DERIVATIVES OF BENZIMIDAZOLE AND IMIDAZO-PYRIDINE AND THEIR USE AS MEDICAMENTS
  申请人：POITOUT Lydie

  公开号：US20090270372A1

  公开（公告）日：2009-10-29

  A subject of the present Application is novel derivatives of benzimidazole and imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.

  本申请的主题是苯并咪唑和咪唑吡啶的新衍生物，它们对于某些亚型的黑色素皮质素受体，特别是MC4受体具有良好的亲和力。它们特别适用于治疗涉及一个或多个黑色素皮质素受体的病理条件和疾病。本发明还涉及含有上述产物的制药组合物。
• Novel derivatives of benzimidazale and imidazo-pyridine and their use as medicaments
  申请人：Poitout Lydie

  公开号：US20080139619A1

  公开（公告）日：2008-06-12

  A subject of the present application is novel derivatives of benzimidazole and imidazo-pyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.

  本申请的主题是苯并咪唑和咪唑吡啶的新衍生物，它们对于某些亚型的黑素皮质素受体，特别是MC4受体具有良好的亲和力。它们特别适用于治疗涉及一个或多个黑素皮质素受体的病理条件和疾病。本发明还涉及含有上述产品的制药组合物。
• Compositions and methods for visible-light-controlled ruthenium-catalyzed olefin metathesis
  申请人：The Trustees of Columbia University In The City of New York

  公开号：US11331656B2

  公开（公告）日：2022-05-17

  The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.

  本公开提供了将第一烯基或炔基与第二烯基或炔基进行偏析的组合物和方法，该组合物包括钌偏析催化剂和由可见光激活的光氧化催化剂。