2-aminonorborn-5-ene | 52430-93-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-aminonorborn-5-ene
• 英文别名: Bicyclo[2.2.1]hept-5-en-2-amine
• CAS: 52430-93-0
• 化学式: C₇H₁₁N
• mdl: MFCD24393653
• 分子量: 109.171
• InChiKey: CYMRDAUUJQRTGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-aminonorborn-5-ene 在 盐酸 作用下， 生成 (2S,3S,4R,5R)-5-[6-(Bicyclo[2.2.1]hept-5-en-2-ylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide
  参考文献：
  名称：

  N6-(5,6-epoxynorbornyl)adenosine analogs as A1 adenosine agonists

  摘要：

  A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N-6 position have been synthesised and evaluated as A(1)-adenosine receptor ligands. Compound 9 emerged with potent affinity (EC50 = 1.1 nM). (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00668-4
• 作为产物：
  描述：

  5-异硫氰酸双环并[2.2.1]庚烯 在 甲苯-3,4-二硫酚 作用下， 以 甲醇 为溶剂， 以72%的产率得到2-aminonorborn-5-ene
  参考文献：
  名称：

  Alkyl and aryl isothiocyanates as masked primary amines

  摘要：

  Primary and secondary (but not tertiary) alkyl as well as aryl isothiocyanates react rapidly with 4-methyl-1,2-benzenedithiol (1) in methanol at room temperature, releasing the corresponding amines in good yields. This mild and simple procedure for unmasking amines proceeds chemospecifically with isothiocyanates even in the presence of such normally electrophilic and reactive functionalities as carboxylate ester and N-alkylphthalimide.

  DOI：

  10.1016/s0040-4039(00)92512-7

文献信息

• [EN] 2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS VLA-4 INHIBITORS<br/>[FR] DERIVES DE 2,6-QUINOLINYLE ET DE 2,6-NAPHTYLE, LEURS PROCEDES DE PREPARATION ET LEUR UTILISATION COMME INHIBITEURS DE VLA-4
  申请人：UCB SA

  公开号：WO2003093237A1

  公开（公告）日：2003-11-13

  The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.

  本发明涉及式(I)的2,6-喹啉基和2,6-萘基衍生物，制备它们的方法，含有它们的药物组合物以及它们作为治疗VLA-4依赖性炎症性疾病的药物的用途，例如哮喘、过敏性鼻炎、鼻窦炎、结膜炎、食物过敏、牛皮癣、荨麻疹、瘙痒、湿疹、类风湿关节炎、炎症性肠病、多发性硬化和动脉粥样硬化等。式(I)：其中X为N或CH。
• Metastable isomers of acetonitrile: syntheses of vinylideneamine and Δ¹-azirine
  作者：Jean-Claude Guillemin、Jean-Marc Denis、Marie-Claire Lasne、Jean-Louis Ripoll

  DOI：10.1039/c39830000238

  日期：——

  The flash vacuum thermolysis and/or gas–solid phase multistep sequences allow the synthesis of vinylideneamine and a safe, preparative-scale synthesis of Δ1-azirine.

  通过闪蒸真空热解和/或气固相多步顺序，可以合成亚乙烯基胺，并安全地制备出δ1-氮丙啶。
• Substituted Oxadiazoles for Combating Phytopathogenic Fungi
  申请人：BASF SE

  公开号：US20200045974A1

  公开（公告）日：2020-02-13

  The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof; and to their use for controlling phytopathogenic fungi; and to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi, the plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; and to agrochemical compositions comprising at least one compound of the formula I; and to agrochemical compositions further comprising seeds.

  本发明涉及公式I的新型三氟甲氧噻二唑，或其N-氧化物，或其农业上有用的盐；以及它们用于控制植物病原真菌的用途；以及一种用于防治植物病原真菌的方法，该方法包括使用公式I的至少一种化合物，或其N-氧化物，或其农业上可接受的盐的有效量来处理真菌、植物、土壤或需要受到真菌攻击保护的种子；以及包含至少一种公式I的农药组合物；以及进一步包含种子的农药组合物。
• [EN] DEGRADABLE POLYMERIC TISSUE SCAFFOLD<br/>[FR] ÉCHAFAUDAGE DE TISSU POLYMÈRE DÉGRADABLE
  申请人：MOSAIC BIOSCIENCES INC

  公开号：WO2020232270A1

  公开（公告）日：2020-11-19

  The present disclosure relates generally to degradable polymeric scaffolds, methods of making them, and their use in the biomedical field.

  本公开涉及可降解聚合物支架，其制备方法以及在生物医学领域中的应用。
• [EN] NOVEL A1 ADENOSINE RECEPTOR AGONISTS AND ANTIAGONISTS<br/>[FR] NOUVEAUX AGONISTES ET ANTAGONISTES DE RECEPTEURS DE L'ADENOSINE A1
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：WO1995011904A1

  公开（公告）日：1995-05-04

  (EN) Adenosine and xanthine derivatives, and compositions comprising those compounds, are potent selective agonists and antagonists of adenosine receptors. The derivatives and compositions are used to treat conditions, including certain cardiac arrhythmias.(FR) On décrit des dérivés d'adénosines et de xanthines, qui sont de puissants agonistes et antagonistes sélectifs de récepteurs d'une adénosine, ainsi que des compositions contenant ces composés. On utilise ces dérivés et compositions pour traiter des pathologies telles que certaines arythmies cardiaques.

  (中文) 腺苷和黄嘌呤衍生物，以及含有这些化合物的组合物，是腺苷受体的强效选择性激动剂和拮抗剂。这些衍生物和组合物用于治疗包括某些心律失常在内的疾病。