溴化琥珀胆碱 | 55-94-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 溴化琥珀胆碱
• 英文名称: Suxamethonium bromide
• 英文别名: trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium;dibromide
• CAS: 55-94-7
• 化学式: C14H30Br2N2O4
• 分子量: 450.21
• InChiKey: HKDOIORVQFUBKO-UHFFFAOYSA-L

物化性质

• 熔点：
  225°
• 溶解度：
  可微溶于水

计算性质

• 辛醇/水分配系数(LogP)：
  -5.73
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 危险等级：
  6.1(b)
• 包装等级：
  III
• 危险类别：
  6.1(b)

文献信息

• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Multi-Layer Tablets and Bioadhesive Dosage Forms
  申请人：Nangia Avinash

  公开号：US20080311191A1

  公开（公告）日：2008-12-18

  Bioadhesives coatings increase the gastrointestinal retention time of orally-ingested medicaments. Certain bioadhesive coatings producing a fracture strength of at least 100 N/m 2 , as measured on rat intestine, when applied to at least one surface of a pharmaceutical dosage form for oral delivery of a drug, result in a gastrointestinal retention time of at least 4 hours in a fed beagle dog model, during which the drug is released from the dosage form. Multi-layer tablets, particularly those including hydrophobic excipients, are useful in administering hygroscopic and/or deliquescent drugs. In addition, varying the amount of drug in multi-layer tablets allows the release rate of the drug to be controlled.

  生物粘合剂涂层可以增加口服药物的胃肠道保留时间。当应用于至少一种药物剂型的表面以口服给药时，产生至少100 N/m²的断裂强度的某些生物粘合剂涂层（在大鼠肠道上测量）可导致在饲养的比格犬模型中至少保留4小时的胃肠道保留时间，在此期间药物从剂型中释放。多层片剂，特别是包括疏水助剂的多层片剂，可用于给予吸湿性和/或易溶性药物。此外，改变多层片剂中药物的量可以控制药物的释放速率。
• Transdermal device containing polyvinylpyrrolidone as solubility enhancer
  申请人：NOVEN PHARMACEUTICALS, INC.

  公开号：EP1329225A2

  公开（公告）日：2003-07-23

  A blend of at least three polymers, including a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. Soluble polyvinylpyrrolidone increases the solubility of drug without negatively affecting the adhesivity of the composition or the rate of drug delivery from the pressure-sensitive adhesive composition

  包括可溶性聚乙烯吡咯烷酮在内的至少三种聚合物与药物的混合物为透皮给药系统提供了一种压敏粘合剂组合物，当压敏粘合剂组合物与人体皮肤接触时，药物可从压敏粘合剂组合物中通过真皮输送。可溶性聚乙烯吡咯烷酮增加了药物的溶解度，而不会对组合物的粘附性或压敏胶组合物的给药速率产生负面影响。
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：M. Technique Co., Ltd.

  公开号：EP3318543A1

  公开（公告）日：2018-05-09

  The present invention addresses the problem of providing a method for producing an organic compound by a phase transfer catalysis reaction using a forced thin-film microreactor. In the present invention, at least two types of fluid, which are a first fluid and a second fluid are used; the first fluid and the second fluid are not miscible with each other; at least the first fluid thereamong includes one or two items selected from the three items of an organic compound, a reactant, and a phase transfer catalyst; from among the fluids other than the first fluid, at least the second fluid includes at least one item from among the items not selected from the three items; the overall first fluid and second fluid contain all of the three items; and each of the fluids meraged

  本发明要解决的问题是提供一种利用强制薄膜微反应器通过相转移催化反应生产有机化合物的方法。在本发明中，至少使用了两种流体，即第一流体和第二流体；第一流体和第二流体互不相溶；至少第一流体中包括从有机化合物、反应物和相转移催化剂三者中选出的一个或两个项目；在除第一流体以外的流体中，至少第二流体包括从未曾从三者中选出的项目中选出的至少一个项目；第一流体和第二流体总体上包含三者中的所有项目；并且每种流体都合并了