4-[2-(4-iodophenyl)vinyl]phenylamine | 1075218-63-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-[2-(4-iodophenyl)vinyl]phenylamine
• 英文别名: 4-[(E)-2-(4-iodophenyl)ethenyl]aniline
• CAS: 1075218-63-1
• 化学式: C₁₄H₁₂IN
• 分子量: 321.16
• InChiKey: RKWISNZXNZGLEZ-OWOJBTEDSA-N

物化性质

• 熔点：
  213.4-215.2 °C
• 沸点：
  429.2±34.0 °C(Predicted)
• 密度：
  1.630±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-[2-(4-iodophenyl)vinyl]phenylamine 在 Pd(PPh3)4 (Bu₃Sn)2 、 三乙胺 作用下， 生成 4-[2-(4-tributylstannanylphenyl)vinyl]phenylamine
  参考文献：
  名称：

  MOLECULAR PROBES FOR IMAGING OF MYELIN

  摘要：

  用于标记髓鞘的分子探针包括一种荧光基团,即反式芪衍生物。

  公开号：

  US20110189090A1
• 作为产物：
  描述：

  diethyl 4-nitrobenzyl phosphate 在 sodium hydride 、 tin(ll) chloride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 4-[2-(4-iodophenyl)vinyl]phenylamine
  参考文献：
  名称：

  Molecular probes for imaging of myelin

  摘要：

  用于标记髓鞘的分子探针包括一种荧光基团-反-芪衍生物。

  公开号：

  US09987379B2

文献信息

• MOLECULAR PROBES FOR DETECTING LIPID COMPOSITION
  申请人：Case Western Reserve University

  公开号：US20140079635A1

  公开（公告）日：2014-03-20

  A method of detecting myelin in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.

  一种检测受试者髓鞘的方法，包括向受试者施加一种分子探针，该探针包括一种荧光转-史蒂本衍生物，并检测受试者感兴趣的组织中分子探针的数量或分布。
• Molecular Probes for Imaging Myelinated White Matter in CNS
  作者：Chunying Wu、Jinjun Wei、Donghua Tian、Yue Feng、Robert H. Miller、Yanming Wang

  DOI：10.1021/jm8003637

  日期：2008.11.13

  Abnormalities and changes in myelination in the brain are seen in many neurodegenerative disorders such as multiple sclerosis (MS). Direct detection and quantification of myelin content in vivo is desired to facilitate diagnosis and therapeutic treatments of myelin-related diseases. The imaging studies require use of myelin-imaging agents that readily enter the brain and selectively bind to myelinated regions. For this purpose, we have systematically evaluated a series of stilbene derivatives as myelin imaging agents. Spectrophotometry-based and radioligand-based binding assays showed that these stilbene derivatives exhibited relatively high myelin-binding affinities. In vitro myelin staining exhibited that the compounds selectively stained intact myelinated regions in wild type mouse brain. In situ tissue staining demonstrated that the compounds readily entered the mouse brain and selectively labeled myelinated white matter regions. These Studies suggested that these stilbene derivatives can be used as myelin-imaging probes to monitor myelin pathology in vivo.
• Molecular Probes for Detecting Lipids
  申请人：Case Western Reserve University

  公开号：US20170176469A1

  公开（公告）日：2017-06-22

  A method of detecting aberrant lipid accumulation in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative or stilbenzene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.
• US9987379B2
  申请人：——

  公开号：US9987379B2

  公开（公告）日：2018-06-05
• [EN] MOLECULAR PROBES FOR IMAGING OF MYELIN<br/>[FR] SONDES MOLÉCULAIRES POUR L'IMAGERIE DE LA MYÉLINE
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2010039815A1

  公开（公告）日：2010-04-08

  A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.