4'-(3-hydroxypropyl)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylic acid | 942259-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4'-(3-hydroxypropyl)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylic acid
• 英文别名: 4-[4-(3-Hydroxypropyl)-3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)phenyl]benzoic acid
• CAS: 942259-93-0
• 化学式: C₃₀H₃₄O₃
• 分子量: 442.598
• InChiKey: BWHDXGIMFXWPLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 4'-(3-hydroxypropyl)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 14.0h， 以90%的产率得到4'-(3-hydroxypropyl)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylic acid
  参考文献：
  名称：

  Biphenyl compound selective agonists of gamma RAR receptors

  摘要：

  具有以下化学式（I）的二苯基化合物：对于预防/治疗与RAR gamma受体激活不足有关的病理学，例如用于治疗与细胞分化和/或增殖紊乱有关的病理学，用于治疗痤疮和牛皮癣等病理学是有用的。

  公开号：

  US20090036536A1

文献信息

• Bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US10377694B2

  公开（公告）日：2019-08-13

  The invention relates to new compounds of the general formula (I): as well as the use thereof in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, in particular), or in the use of cosmetic compositions.

  本发明涉及通式 (I) 的新化合物： 以及将其用于人类或兽类医药（尤其是皮肤病、风湿病、呼吸系统疾病、心血管疾病和眼科疾病）的药物组合物中，或用于化妆品组合物中。
• Biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US10995052B2

  公开（公告）日：2021-05-04

  Compounds of general formula (I) are described. Also described, is the use of such compounds in pharmaceutical compositions for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmologic disorders, in particular), or in cosmetic compositions.

  本文描述了通式（I）的化合物。 此外，还介绍了此类化合物在药物组合物中的用途，这些药物组合物可用于人类医学或兽医学（尤其是皮肤病、风湿病、呼吸系统疾病、心血管疾病和眼科疾病），也可用于化妆品组合物。
• DERIVES BIPHENYLIQUES AGONISTES SELECTIFS DU RECEPTEUR RAR-GAMMA
  申请人：Galderma Research & Development

  公开号：EP1963249A1

  公开（公告）日：2008-09-03
• NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US20180079707A1

  公开（公告）日：2018-03-22

  The invention relates to new compounds of the general formula (I): as well as the use thereof in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, in particular), or in the use of cosmetic compositions.
• NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US20190337881A1

  公开（公告）日：2019-11-07

  Compounds of general formula (I) are described. Also described, is the use of such compounds in pharmaceutical compositions for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmologic disorders, in particular), or in cosmetic compositions.