2-(4-羟苯基)-2H-异喹啉-1-酮 | 20434-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 2-(4-羟苯基)-2H-异喹啉-1-酮
• 英文名称: 2-(4-Hydroxyphenyl)isoquinolin-1(2H)-one
• 英文别名: 2-(4-hydroxyphenyl)isoquinolin-1-one
• CAS: 20434-92-8
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.25
• InChiKey: IOQLQCNDZDXQEY-UHFFFAOYSA-N

物化性质

• 沸点：
  531.4±50.0 °C(Predicted)
• 密度：
  1.298±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

文献信息

• [EN] TREATMENT OF DISEASES BY EPIGENETIC REGULATION<br/>[FR] TRAITEMENT DE MALADIES PAR LA RÉGULATION ÉPIGÉNÉTIQUE
  申请人：RVX THERAPEUTICS INC

  公开号：WO2013156869A1

  公开（公告）日：2013-10-24

  The present application is directed to the use of substituted 2-phenyl-3H-quinazolin-4-ones and analogs for inhibiting BET (bromodomain and extra terminal domain) proteins. The disclosed compounds can be used for the treatment of cancers that exhibit c-myc overexpression, cancers that overexpress n-myc, and cancers that rely on the recruitment of p-TEFb to regulate activated oncogenes, such as Burkitt's lymphoma, acute myelogenous leukemia, multiple myeloma, aggressive human medulloblastoma, hematological, epithelial cancers, lung cancers, breast cancers, colon carcinomas, midline carcinomas, mesenchymal tumors, hepatic tumors, renal tumors and neurological tumors. Other diseases or disorders that can be treated with the disclosed compounds include autoimmune or inflammatory diseases or conditions, diseases or disorders caused by bacterial or viral infection.