1-phenyl-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione | 40103-85-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-phenyl-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione
• 英文别名: 1-phenyl-2-[3-(trifluoromethyl)phenyl]ethane-1,2-dione
• CAS: 40103-85-3
• 化学式: C₁₅H₉F₃O₂
• 分子量: 278.23
• InChiKey: CYHQQHNKADORRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-phenyl-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 3-Trifluormethylbenzilsaeure
  参考文献：
  名称：

  含氟或三氟甲基的苯甲酸二烷基氨基烷基酯的合成和药理活性。

  摘要：

  DOI：

  10.1021/jm00293a040
• 作为产物：
  描述：

  间三氟甲基苯腈 在 selenium(IV) oxide 作用下， 以 乙醚 、 溶剂黄146 为溶剂， 生成 1-phenyl-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione
  参考文献：
  名称：

  含氟或三氟甲基的苯甲酸二烷基氨基烷基酯的合成和药理活性。

  摘要：

  DOI：

  10.1021/jm00293a040

文献信息

• Vanilloid receptor ligands and their use in treatments
  申请人：Gore Keshav Vijay

  公开号：US20060084640A1

  公开（公告）日：2006-04-20

  Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  治疗性苯并咪唑及含有它们的组合物，用于治疗急性、炎症性和神经痛、牙痛、普通头痛、偏头痛、集群头痛、混合血管和非血管综合征、紧张性头痛、一般炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠道疾病、炎症性眼部疾病、炎症性或不稳定的膀胱疾病、牛皮癣、带有炎症成分的皮肤疾病、慢性炎症症状、炎症性疼痛及相关的过敏性疼痛和触痛、神经痛及相关的过敏性疼痛和触痛、糖尿病性神经病痛、烧灼性疼痛、交感神经维持性疼痛、去神经症候群、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、消化或血管区域内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠道疾病、胃溃疡、十二指肠溃疡、腹泻、由坏死性剂引起的胃病变、毛发生长、血管运动性或过敏性鼻炎、支气管疾病或膀胱疾病。
• Catalyst-Controlled Highly Selective Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones, and Diketones
  作者：Yijin Su、Xiang Sun、Guolin Wu、Ning Jiao

  DOI：10.1002/anie.201303917

  日期：2013.9.9

  Oxygen? That's radical! A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst‐controlled highly chemoselective coupling and oxygenation of olefins has been developed. The method is simple and practical, can be switched by the selection of different catalysts, and employs molecular oxygen as both an oxidant and a reagent.

  氧？太过激了！已开发出一种通过催化剂控制的烯烃高度化学选择性偶联和氧合直接合成取代的醇，酮和二酮的方法。该方法简单实用，可以通过选择不同的催化剂进行切换，并采用分子氧作为氧化剂和试剂。
• Visible-Light-Induced Photocatalytic Oxidative Decarboxylation of Cinnamic Acids to 1,2-Diketones
  作者：Shiv Chand、Anand Kumar Pandey、Rahul Singh、Krishna Nand Singh

  DOI：10.1021/acs.joc.1c00322

  日期：2021.5.7

  A concerted metallophotoredox catalysis has been realized for the efficient decarboxylative functionalization of α,β-unsaturated carboxylic acids with aryl iodides in the presence of perylene bisimide dye to afford 1,2-diketones.

  已经实现了协同的金属光氧化还原催化，以在of双酰亚胺染料的存在下用芳基碘将α，β-不饱和羧酸有效地脱羧官能化，得到1,2-二酮。
• Mild Mn(OAc)₃-Mediated Aerobic Oxidative Decarboxylative Coupling of Arylboronic Acids and Arylpropiolic Acids: Direct Access to Diaryl 1,2-Diketones
  作者：Wen-Xin Lv、Yao-Fu Zeng、Shang-Shi Zhang、Qingjiang Li、Honggen Wang

  DOI：10.1021/acs.orglett.5b01265

  日期：2015.6.19

  A simple and efficient method for the synthesis of diaryl 1,2-diketones has been developed. The reaction represents the first example of diaryl 1,2-diketones that are synthesized directly from arylboronic acids and arylpropiolic acids by a radical pathway in moderate to good yields. This reaction proceeds under mild reaction conditions and with good tolerance of a variety of functional groups. Preliminary

  已经开发了一种简单有效的合成二芳基1,2-二酮的方法。该反应代表二芳基1,2-二酮的第一个实例，该二芳基1,2-二酮是通过自由基途径由芳基硼酸和芳基丙酸直接合成的，产率中等至良好。该反应在温和的反应条件下进行，并且对各种官能团具有良好的耐受性。进行了初步的力学研究。
• Cobalt(<scp>ii</scp>) catalyzed C(sp)–H bond functionalization of alkynes with phenyl hydrazines: facile access to diaryl 1,2-diketones
  作者：Jaideep B. Bharate、Sheenu Abbat、Rohit Sharma、Prasad V. Bharatam、Ram A. Vishwakarma、Sandip B. Bharate

  DOI：10.1039/c5ob00419e

  日期：——

  A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)–H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(II) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility

  已经描述了乙酰丙酮钴通过C（sp）–H键官能化催化炔烃的氧化二酮化反应。该反应涉及自由基机理，其中由苯基肼形成的苯基与Co（II）活化的炔烃偶合以产生1，2-二酮。反应在室温下在DMF中使用Ag 2 O /空气作为氧化体系进行。已证明该方案可用于合成一系列咪唑类化合物，其中包括有效的血小板凝集抑制剂曲非那格雷。