1-Chlor-7-diethylamino-heptan | 56376-58-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Chlor-7-diethylamino-heptan
• 英文别名: 7-Chlor-1-diethylaminoheptan；diethyl-(7-chloro-heptyl)-amine；Diaethyl-(7-chlor-heptyl)-amin；7-Chlor-1-diaethylamino-heptan；7-chloro-N,N-diethylheptan-1-amine
• CAS: 56376-58-0
• 化学式: C₁₁H₂₄ClN
• 分子量: 205.771
• InChiKey: NRWFNFLRKOQXCX-UHFFFAOYSA-N

物化性质

• 沸点：
  126 °C(Press: 15 Torr)
• 密度：
  0.8989 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Chlor-7-diethylamino-heptan 在 硫酸 作用下， 生成 8-Diethylamino-1-benzoylamino-1-phenyloctan
  参考文献：
  名称：

  Borisova,E.Ya. et al., Journal of Organic Chemistry USSR (English Translation), 1975, vol. 11, p. 933 - 936

  摘要：

  DOI：
• 作为产物：
  描述：

  7-chloroheptanoyl chloride 在 lithium aluminium tetrahydride 作用下， 以 苯 为溶剂， 生成 1-Chlor-7-diethylamino-heptan
  参考文献：
  名称：

  Solov'ev,V.M.; Skoldinov,A.P., Journal of general chemistry of the USSR, 1962, vol. 32, p. 432 - 438

  摘要：

  DOI：

文献信息

• Coulthard; Levene; Pyman, Biochemical Journal, 1933, vol. 27, p. 736
  作者：Coulthard、Levene、Pyman

  DOI：——

  日期：——
• Altman, Recueil des Travaux Chimiques des Pays-Bas, 1938, vol. 57, p. 951
  作者：Altman

  DOI：——

  日期：——
• Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents
  作者：Maurice P. LaMontagne、Dinesh Dagli、M. Sami Khan、Peter Blumbergs

  DOI：10.1021/jm00183a004

  日期：1980.9

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.
• Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity
  作者：Serena Scapecchi、Elisabetta Martini、Cristina Bellucci、Michela Buccioni、Silvia Dei、Luca Guandalini、Dina Manetti、Cecilia Martelli、Gabriella Marucci、Rosanna Matucci

  DOI：10.1016/j.farmac.2004.08.003

  日期：2004.12

  The synthesis and preliminary pharmacological profile of a new series of muscarinic antagonists, derived from previously studied 2,2-diphenyl-2-ethylthio-acetic acid esters, are reported. The parent molecules were decorated with linkers of different length, carrying an amino group to catch a putative anionic function outside the recognition site of the receptor. It was hoped that the interception of this function would give molecules with higher potency and selectivity. The attempt has not been successful, but a new series of compounds with a peculiar pharmacological profile has been identified.
• DAGLI D.; KHAN M. S.; BLUMBERGS P., J. MED. CHEM., 1980, 23, NO 9, 981-985
  作者：DAGLI D.、 KHAN M. S.、 BLUMBERGS P.

  DOI：——

  日期：——