Metabolic studies were performed in rats using single low and single high doses of radiolabeled thiodicarb. The major routes of elimination were expiration (CO2 and acetonitrile) and urination. Tissue residues contained 7-9% of the dose at 7 days post dose and may reflect the metabolism of (14)C-acetonitrile into the body's C-2 and C-1 pools and subsequent interaction with, or incorporation into natural products. The major terminal metabolites of thiodicarb in the rat are CO2 and acetonitrile. The major urinary metabolite is a labile unknown that represents 50% of the urinary radiolabel. No acetamide was detected in any of the tissues. The RBCs contained only residue that cannot be extracted by organic solvents or water, indicating the presence of radiolabel incorporated into natural products or of material tightly bound to hemoglobin.
In a metabolism study in monkeys, some thiodicarb (syn, syn-isomer) radiolabel was converted via in vivo metabolism to syn-methomyl and subsequently isomerized to anti-methomyl, with ~0.8-1.0% (lower limit) to 2.6-3.3% (upper limit) by weight of thiodicarb being converted to acetamide and excreted in the urine.
IDENTIFICATION AND USE: Thiodicarb is a solid. It is used as insecticide, and as a seed treatment/protectant. HUMAN EXPOSURE AND TOXICITY: It is a probable human carcinogen. ANIMAL STUDIES: Instillation in rabbit eyes resulted in slight irritation. Thiodicarb produced no irritation during the primary dermal irritation study in rabbits. Thiodicarb induced a weak dermal sensitization reaction in guinea pigs. Marked systemic organ toxicity was noted in rats after exposure to thiodicarb. In rats it decreased red blood cell cholinesterase activity, and decreased hemoglobin. In dogs it decreased hematocrit and hemoglobin. Skin application in rabbits caused macrocytic anemia, erythema, and edema. Other dermal study in rabbits described decreased erythrocytes, decreased hemoglobin, and decreased body weight. Male rats treated with thiodicarb displayed an increased incidence of interstitial cell tumors in the testes compared to the concurrent control males, and the incidence was also greater than the historical control. In mice it produced increased incidences of hepatocellular tumors in both sexes. Developmental studies in rats demonstrated decreased fetal body weight and an increase in the number of litters and fetuses with developmental variations. Thiodicarb did not induce a mutagenic response in the Ames assay, with or without metabolic activation. Thiodicarb induced dose-related increased mutant frequencies in mouse lymphoma TK+/- cells, with and without metabolic activation and is considered to have an equivocal weak effect in the mouse lymphoma forward mutation assay. Thiodicarb, with or without metabolic activation, did not cause a clastogenic response in the chromosomes of Chinese hamster ovary cells. Thiodicarb is considered inactive in the primary rat hepatocyte unscheduled DNA synthesis assay. ECOTOXICITY STUDIES: Thiodicarb is moderately toxic to bees as direct treatment, but is not toxic after spray residues have dried.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
癌症分类：B2组可能的人类致癌物
Cancer Classification: Group B2 Probable Human Carcinogen
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Other Poison - Carbamate
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
ACGIH Carcinogen - Confirmed Animal.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
毒理性
毒性数据
大鼠LC50 = 220毫克/立方米/4小时
LC50 (rat) = 220 mg/m3/4h
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Ensure that a clear airway exists. Intubate the patient and aspirate the secretions with a large bore suction device if necessary. Administer oxygen by mechanically assisted pulmonary ventilation if respiration is depressed. Improve tissue oxygenation as much as possible before administering atropine, so as to minimize the risk of ventricular fibrillation. In severe poisonings, it may be necessary to support pulmonary ventilation mechanically for several days. /N-methyl carbamate insecticides/
Metabolic studies were performed in rats using single low and single high doses of radiolabeled thiodicarb. The major routes of elimination were expiration (CO2 and acetonitrile) and urination. Tissue residues contained 7-9% of the dose at 7 days post dose and may reflect the metabolism of (14)C-acetonitrile into the body's C-2 and C-1 pools and subsequent interaction with, or incorporation into natural products.
