1-(1-Bromocyclohexyl)propan-1-one | 1140528-66-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1-(1-Bromocyclohexyl)propan-1-one
• 英文别名: 1-(1-bromocyclohexyl)propan-1-one
• CAS: 1140528-66-0
• 化学式: C₉H₁₅BrO
• 分子量: 219.121
• InChiKey: GYKDYKKKQLYINH-UHFFFAOYSA-N

物化性质

• 沸点：
  246.9±23.0 °C(predicted)
• 密度：
  1.312±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己基甲乙酮 在 ammonium cerium (IV) nitrate 、 potassium bromide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成 1-(1-Bromocyclohexyl)propan-1-one
  参考文献：
  名称：

  Synthesis of γ-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides

  摘要：

  A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.114

文献信息

• Synthesis of γ-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides
  作者：Brian M. Casey、Cynthia A. Eakin、Robert A. Flowers

  DOI：10.1016/j.tetlet.2008.12.114

  日期：2009.3

  A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.