cyclooctanone semicarbazone | 40338-24-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cyclooctanone semicarbazone
• 英文别名: Cyclooctanon-semicarbazon；2-cyclooctylidene-hydrazinecarboxamide；Cyclooctanonsemicarbazon；Semicarbazono-cyclooctan；(cyclooctylideneamino)urea
• CAS: 40338-24-7
• 化学式: C₉H₁₇N₃O
• mdl: MFCD00086771
• 分子量: 183.253
• InChiKey: VVZRTXGIBUIDGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  cyclooctanone semicarbazone 在 盐酸 、 Tonsil 作用下， 以 乙酸乙酯 为溶剂， 反应 2.0h， 以94.1%的产率得到环辛酮
  参考文献：
  名称：

  Cano, A. C.; Delgado, F; Cordoba, A. A., Synthetic Communications, 1988, vol. 18, # 16-17, p. 2051 - 2054

  摘要：

  DOI：
• 作为产物：
  描述：

  环庚酮 在 甲醇 作用下， 生成 cyclooctanone semicarbazone
  参考文献：
  名称：

  The Preparation of Cyclic Ketones by Ring Enlargement

  摘要：

  DOI：

  10.1021/ja01874a021

文献信息

• Microwave synthesis of bis(cycloalkeno)-1,4-diselenins: a novel source of Se for CdSe QDs
  作者：Aditi A. Jadhav、Priyesh V. More、Pawan K. Khanna

  DOI：10.1039/c7nj00793k

  日期：——

  cycloalkeno-1,2,3-selenadiazoles by a microwave irradiation (MW) method. The bi-radical dimerization reaction of 1,2,3-selenadiazoles was performed by a new synthetic strategy under solvent-free conditions using 100 Watt microwave irradiation for about 20 minutes. The current synthesis afforded a feasible approach for the preparation of various 1,4-diselenins. The so-prepared alkyl selenides were characterized

  本文介绍了通过微波辐射（MW）方法由相应的环烯基1,2,3-硒代二唑形成一系列的双（环烯基）-1,4-二硒精。1,2,3-硒代二唑的双自由基二聚反应是通过一种新的合成策略在无溶剂条件下使用100瓦特微波辐照约20分钟进行的。当前的合成为制备各种1，4-二硒精提供了可行的方法。如此制备的烷基硒化物通过各种光谱学工具表征。紫外线可见，FTIR，1 H，13 C，DEPT和77Se NMR光谱，ESI-MS和TGA分析。另外，双（环庚烯）-1,4-二硒精已被有效地用作合成CdSe量子点（QDs）的新型硒前体。这种富含硒的前体也可能用于制备其他金属硒化物。
• Composition and method for lower blood sugar containing
  申请人：Hoechst Aktiengesellschaft

  公开号：US03932658A1

  公开（公告）日：1976-01-13

  N-[4-(.beta.-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-N'-cycl opentyl-urea of the formula ##SPC1## Having a long-lasting and strong hypoglycemic action in the treatment of diabetes mellitus and a process for its manufacture.

  N-[4-(β-<2-甲氧基-5-氯苯甲酰胺>-乙基)-苯磺酰]-N'-环戊基脲，其化学式为##SPC1##，在糖尿病治疗中具有持久而强效的降血糖作用，并提供其制备方法。
• Interrupted Dance of Five Heteroatoms: Reinventing Ozonolysis to Make Geminal Alkoxyhydroperoxides from C═N Bonds
  作者：Ivan A. Yaremenko、Dmitri I. Fomenkov、Roman A. Budekhin、Peter S. Radulov、Michael G. Medvedev、Nikolai V. Krivoshchapov、Liang-Nian He、Igor V. Alabugin、Alexander O. Terent’ev

  DOI：10.1021/acs.joc.4c00233

  日期：2024.4.19

  Four heteroatoms dance in the cascade of four pericyclic reactions initiated by ozonolysis of C═N bonds. Switching from imines to semicarbazones introduces the fifth heteroatom that slows this dance, delays reaching the thermodynamically favorable escape path, and allows efficient interception of carbonyl oxides (Criegee intermediates, CIs) by an external nucleophile. The new three-component reaction

  四个杂原子在由 C=N 键臭氧分解引发的四个周环反应的级联中起舞。从亚胺切换到缩氨基脲引入了第五个杂原子，它减缓了这种舞蹈，延迟了到达热力学上有利的逃逸路径，并允许外部亲核试剂有效拦截羰基氧化物（Criegee中间体，CI）。醇、臭氧和肟/缩氨基脲的新型三组分反应极大地促进了单过氧缩醛（烷氧基氢过氧化物）的合成。
• Conversion of the carbonyl group to CF2 using iodine monofluoride (IF)
  作者：Shlomo Rozen、Dov Zamir

  DOI：10.1021/jo00015a024

  日期：1991.7

  A novel method for the transformation of CO --> CF2 is described. The easily made hydrazone derivatives of the carbonyl moiety are reacted under mild conditions with IF prepared directly from the corresponding elements. Various hydrazones have been examined and compared with each other. Unsubstituted ones are usually the most suitable although they are not always easy to purify and store. N-Methyl- and N,N-dimethylhydrazones also give quite satisfactory results. The more easily made dinitrophenyl hydrazones (DNPs), semicarbazones, and tosylhydrazones also react, but the yields of the desired CF2 compounds are usually lower. Oximes could also be successfully reacted. The two main byproducts of the reaction are the parent carbonyl compounds, which can be recycled, and the alpha-iododifluoro derivatives. The latter upon treatment with LiAlH4 or Bu3SnH were reduced to the desired product, thus increasing the overall yields.
• Meier, Herbert; Trickes, Georg; Laping, Elisabeth, Chemische Berichte, 1980, vol. 113, # 1, p. 183 - 192
  作者：Meier, Herbert、Trickes, Georg、Laping, Elisabeth、Merkle, Ursula

  DOI：——

  日期：——