N-(naphthalen-1-yl)butyramide | 24626-91-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(naphthalen-1-yl)butyramide
• 英文别名: Butyramide, N-1-naphthyl-；N-naphthalen-1-ylbutanamide
• CAS: 24626-91-3
• 化学式: C₁₄H₁₅NO
• 分子量: 213.279
• InChiKey: IRLQJPAKTNBBES-UHFFFAOYSA-N

物化性质

• 保留指数：
  2001

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(naphthalen-1-yl)butyramide 在 potassium tert-butylate 、 C₃₂H₂₉F₅N₄O₂ 作用下， 以 1,4-二氧六环 为溶剂， 反应 36.17h， 生成 (3aS,9S,9aR)-9-(3,5-di-tert-butyl-4-hydroxyphenyl)-9a-ethyl-3a-hydroxy-2-(naphthalen-1-yl)-9,9a-dihydrochromeno[2,3-c]pyrrole-1,3(2H,3aH)-dione
  参考文献：
  名称：

  Organocatalytic and enantioselective [4+2] cyclization between hydroxymaleimides and ortho-hydroxyphenyl para-quinone methide-selective preparation of chiral hemiketals

  摘要：

  已披露了一种高效的和对映选择性的有机催化[4+2]环化反应，首次制备了一系列含有色酮和琥珀酰亚胺骨架的新手性半酮，其结果优异，原子效率达到100%。

  DOI：

  10.1039/d0cc06777f
• 作为产物：
  描述：

  1-萘胺盐酸盐 、 4-Dimethylaminononanmethoiodid 生成 N-(naphthalen-1-yl)butyramide
  参考文献：
  名称：

  Biosynthesis of pinidine

  摘要：

  DOI：

  10.1021/ja01048a031

文献信息

• Organophotoredox‐Mediated Amide Synthesis by Coupling Alcohol and Amine through Aerobic Oxidation of Alcohol
  作者：Sk. Sheriff Shah、Maniklal Shee、Yarra Venkatesh、Amit Kumar Singh、Samya Samanta、N. D. Pradeep Singh

  DOI：10.1002/chem.201904924

  日期：2020.3.23

  formations. The hydrogen-bonded OH group activated the adjacent C-H bond of alcohols towards hydrogen atom transfer (HAT) by a radical species. The quinuclidinium radical cation, generated through single-electron oxidation of quinuclidine by the photocatalyst, employed to abstract a hydrogen atom from the α-C-H bond of alcohols selectively due to a polarity effect-produced α-hydroxyalkyl radical, which

  有机光催化剂[4CzIPN（1,2,3,5-四（咔唑-9-基）-4,6二氰基苯）或5MeOCzBN（2,3,4,5,6-戊基（3,6- [二甲氧基-9 H-咔唑-9-基）苄腈]，喹啉和磷酸四正丁铵（氢键催化剂）用于酰胺键的形成。氢键合的OH基团通过自由基将醇的相邻CH键朝着氢原子转移（HAT）活化。通过光催化剂对奎尼丁进行单电子氧化而生成的奎尼丁鎓自由基阳离子，由于极性效应产生的α-羟烷基自由基选择性地从醇的α-CH键中提取氢原子，随后转化为相应的在有氧条件下的醛。
• 5-Phenyl-4-Methyl-Thiazol-2-Yl-Amine Derivatives as Inhibitors of Phosphatidylin Ositol 3 Kinase Enzymes (PI13) For Treatment of Inflammatory Diseases
  申请人：Bloomfield Graham Charles

  公开号：US20080280871A1

  公开（公告）日：2008-11-13

  in free or salt form, wherein R a , R b , R 2 , R 3 , R 4 and R 5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  在自由或盐形式中，其中Ra，Rb，R2，R3，R4和R5具有规范中指示的含义，对于治疗由磷脂酰肌醇3-激酶介导的疾病是有用的。还描述了含有该化合物的药物组合物以及制备该化合物的过程。
• 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：Bloomfield Graham Charles

  公开号：US20110124624A1

  公开（公告）日：2011-05-26

  Compounds of Formula I: in free or salt form, wherein R a , R b , R 2 , R 3 , R 4 and R 5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  公式I的化合物：以自由或盐形式存在，其中Ra、Rb、R2、R3、R4和R5的含义如规范中所示，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。还描述了含有这些化合物的制药组合物和制备这些化合物的过程。
• CARBON BLACK
  申请人：KONICA MINOLTA BUSINESS TECHNOLOGIES, INC.

  公开号：EP1887050A1

  公开（公告）日：2008-02-13

  Carbon black of the present invention has a number average particle size of Feret's diameter of 5 to 300 nm and a CV value of the number average particle size of Feret's diameter of 5 to 30.

  本发明的炭黑的费氏直径平均粒径数为 5 至 300 纳米，费氏直径平均粒径数的 CV 值为 5 至 30。
• Robertson, Journal of the Chemical Society, 1908, vol. 93, p. 1037
  作者：Robertson

  DOI：——

  日期：——