3-Dimethylaminomethyl-5-phenyl-4,5-dihydro-2(3H)-furanon | 786600-27-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Dimethylaminomethyl-5-phenyl-4,5-dihydro-2(3H)-furanon
• 英文别名: dihydro-3-(dimethylaminomethyl)-5-phenylfuran-2(3H)-one；3-[(Dimethylamino)methyl]-5-phenyloxolan-2-one
• CAS: 786600-27-9
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: HADHEZXCFWQGIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲基碘化镁 、 3-Dimethylaminomethyl-5-phenyl-4,5-dihydro-2(3H)-furanon 以 乙醚 为溶剂， 反应 24.0h， 生成 4-methyl-3-(dimethylaminomethyl)-1-phenylpentane-1,4-diol
  参考文献：
  名称：

  Synthèse et étude pharmacologique de quelques aminolactones et aminotétrahydrofuranes adamantaniques

  摘要：

  This paper describes the synthesis of adamantane aminolactones (AdAL 6 and PhAdAL 16) and their tetrahydrofuran analogues (AdAE 9 and PhAdAE 19). Their convulsant activity was studied in mice. It was found to be weaker than that of the aminolactones or aminotetrahydrofurans, which have a phenyl group in place of the adamantane ring. Studies on the antagonism of the convulsant action of these derivatives, by GABAergic or glycinergic agonists appear to show the simultaneous development of dopaminergic, antiGABAergic (for the AdAE and PhAdAE) and antiglycinergic (for the AdAL and PhAdAL) central activities. These properties could be interesting in the treatment of the late stages of the Parkinson's disease.

  DOI：

  10.1016/0223-5234(91)90213-7
• 作为产物：
  描述：

  3-苯丙烯溴酸酯 在 sodium tetrahydroborate 、 sodium hydride 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 49.0h， 生成 3-Dimethylaminomethyl-5-phenyl-4,5-dihydro-2(3H)-furanon
  参考文献：
  名称：

  Synthèse et étude pharmacologique de quelques aminolactones et aminotétrahydrofuranes adamantaniques

  摘要：

  This paper describes the synthesis of adamantane aminolactones (AdAL 6 and PhAdAL 16) and their tetrahydrofuran analogues (AdAE 9 and PhAdAE 19). Their convulsant activity was studied in mice. It was found to be weaker than that of the aminolactones or aminotetrahydrofurans, which have a phenyl group in place of the adamantane ring. Studies on the antagonism of the convulsant action of these derivatives, by GABAergic or glycinergic agonists appear to show the simultaneous development of dopaminergic, antiGABAergic (for the AdAE and PhAdAE) and antiglycinergic (for the AdAL and PhAdAL) central activities. These properties could be interesting in the treatment of the late stages of the Parkinson's disease.

  DOI：

  10.1016/0223-5234(91)90213-7

文献信息

• Lactone, 6. Mitt. H1-Histaminolytische, neurotrop spasmolytische und zentral sedierende α-Aminomethyl-γ,γ-diaryl-γ-lactone
  作者：Jochen Lehmann、Gisela Gajewski、Gerd Wolf

  DOI：10.1002/ardp.19853180902

  日期：——

  γ‐Aryl‐ und γ,γ‐Diarylbutyrolactone werden durch Formylierung und anschließende reduktive Aminoalkylierung in Verbindungen überführt, die man als lactonverbrückte Aryl‐ 7 bzw. Diaryl‐alkylamine 8,9 betrachten kann. Einige dieser Substanzen wurden auf H1‐histaminolytische, neurotrop spasmolytische und zentrale Wirkung geprüft. Das Spirolacton 9a besitzt die maximale, dem Atropinsulfat überlegene spasmolytische

  γ - 芳基 - 和 γ, γ - 二芳基丁内酯通过甲酰化和随后的还原性氨基烷基化转化为化合物，分别可以视为内酯桥连的芳基 - 7 和二芳基 - 烷基胺 8,9。其中一些物质进行了 H1 组胺溶解、神经营养解痉和中枢作用测试。螺内酯9a解痉作用最大，优于硫酸阿托品，但无抗精神病活性。氨甲基二芳基内酯 8 具有解组织胺、解痉和弱至中度中枢镇静作用。
• Ink composition
  申请人：Fujifilm Corporation

  公开号：EP2042571A1

  公开（公告）日：2009-04-01

  The invention provides an ink composition including (a) a tertiary amine compound having a cationically polymerizable group, (b) a photo-acid generator, and (c) a cationically polymerizable compound. According to the invention, an ink composition in which generation of tackiness on the surface of an image formed is effectively suppressed while maintaining curing sensitivity to irradiation with a radiation ray, blocking is not generated even in the case of laminating prints after image formation, and ejecting property in applying to an inkjet apparatus is good can be provided.

  本发明提供了一种油墨组合物，包括(a)具有阳离子可聚合基团的叔胺化合物，(b)光 酸发生器和(c)阳离子可聚合化合物。根据本发明，可以提供一种墨水组合物，该墨水组合物可以在保持对辐射线照射的固化敏感性的同时，有效抑制在形成的图像表面产生粘性，即使在图像形成后对印刷品进行层压也不会产生阻塞，并且在应用于喷墨设备时具有良好的弹出性能。
• FOSCOLOS, G. B.;FYTAS, G.;KOLOCOURIS, N.;VAMVAKIDES, A., EUR. J. MED. CHEM., 26,(1991) N, C. 59-68
  作者：FOSCOLOS, G. B.、FYTAS, G.、KOLOCOURIS, N.、VAMVAKIDES, A.

  DOI：——

  日期：——
• INK COMPOSITION
  申请人：YOKOI Kazuhiro

  公开号：US20090088492A1

  公开（公告）日：2009-04-02

  The invention provides an ink composition including (a) a tertiary amine compound having a cationically polymerizable group, (b) a photo-acid generator, and (c) a cationically polymerizable compound. According to the invention, an ink composition in which generation of tackiness on the surface of an image formed is effectively suppressed while maintaining curing sensitivity to irradiation with a radiation ray, blocking is not generated even in the case of laminating prints after image formation, and ejecting property in applying to an inkjet apparatus is good can be provided.