ethyl 2-(1,2-diphenylethylamino)benzoate | 1347032-88-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: ethyl 2-(1,2-diphenylethylamino)benzoate
• 英文别名: Ethyl 2-(1,2-diphenylethylamino)benzoate
• CAS: 1347032-88-5
• 化学式: C₂₃H₂₃NO₂
• 分子量: 345.441
• InChiKey: IJALJKJIFOIFRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲醇 、 2-氨基苯甲酸乙酯 在 palladium diacetate 、 sodium 3-(diphenylphosphanyl)benzenesulfonate 作用下， 以 水 为溶剂， 反应 16.0h， 以84%的产率得到ethyl 2-(1,2-diphenylethylamino)benzoate
  参考文献：
  名称：

  Palladium-Catalyzed Benzylation of Unprotected Anthranilic Acids with Benzyl Alcohols in Water

  摘要：

  Palladium-catalyzed benzylation of unprotected anthranilic acids with benzyl alcohols in the presence of Pd(OAc)(2) (5 mol %) and sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol %) in water at 120 degrees C for 16 h gave only dibenzylated anthranilic acids in good yields. Water may play important roles for the smooth generation of the (eta(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.

  DOI：

  10.1021/ol2028042

文献信息

• Palladium-Catalyzed Benzylation of Unprotected Anthranilic Acids with Benzyl Alcohols in Water
  作者：Hidemasa Hikawa、Yuusaku Yokoyama

  DOI：10.1021/ol2028042

  日期：2011.12.16

  Palladium-catalyzed benzylation of unprotected anthranilic acids with benzyl alcohols in the presence of Pd(OAc)(2) (5 mol %) and sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol %) in water at 120 degrees C for 16 h gave only dibenzylated anthranilic acids in good yields. Water may play important roles for the smooth generation of the (eta(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.