vanillyl 8-methyldecanoate | 906465-22-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: vanillyl 8-methyldecanoate
• 英文别名: homodihydrocapsiate；(4-Hydroxy-3-methoxyphenyl)methyl 8-methyldecanoate
• CAS: 906465-22-3
• 化学式: C₁₉H₃₀O₄
• 分子量: 322.445
• InChiKey: JWIMRRWOCVVVRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Topically applied circulation enhancing agent and skin and hair cosmetic and bath agent containing the same
  申请人：Sagawa Koichiro

  公开号：US20060287390A1

  公开（公告）日：2006-12-21

  A topically applied circulation enhancing agent suited for application over the entire body which has good transdermal absorptivity and causes little irritation is provided. A topically applied circulation enhancing agent is provided which contains a fatty acid ester denoted by general formula (1):

  提供一种适用于全身涂抹的促进循环的药剂，具有良好的经皮吸收性且引起少量刺激。提供一种含有一种由通用公式(1)表示的脂肪酸酯的促进循环的局部应用药剂。
• Production method of capsinoid by dehydrating condensation, stabilizing method of capsinoid, and capsinoid composition
  申请人：Amino Yusuke

  公开号：US20070020738A1

  公开（公告）日：2007-01-25

  Capsinoids of formula (3) may be conveniently prepared in a high yield, in a short time, without using a dehydrating agent by esterification of a fatty acid of formula (1) with a hydroxymethylphenol of formula (2) using an enzyme without a solvent or in a low-polar solvent. Addition of a fatty acid represented by formula (4) is effective for stabilizing the ester compound of formula (3). wherein each symbol is as defined in the specification.

  公式（3）的辣椒素类化合物可以通过使用酶而不使用脱水剂，在无溶剂或低极性溶剂中，将公式（1）的脂肪酸与公式（2）的羟甲基酚酯化反应，高产率地、短时间内方便地制备。公式（4）表示的脂肪酸的加入对于稳定公式（3）的酯化合物是有效的。其中每个符号如规范中所定义。
• PRODUCTION METHOD OF CAPSINOID BY DEHYDRATING CONDENSATION, STABILIZING METHOD OF CAPSINOID, AND CAPSINOID COMPOSITION
  申请人：AMINO Yusuke

  公开号：US20100152291A1

  公开（公告）日：2010-06-17

  Capsinoids of formula (3) may be conveniently prepared in a high yield, in a short time, without using a dehydrating agent by esterification of a fatty acid of formula (1) with a hydroxymethylphenol of formula (2) using an enzyme without a solvent or in a low-polar solvent. Addition of a fatty acid represented by formula (4) is effective for stabilizing the ester compound of formula (3). wherein each symbol is as defined in the specification.

  公式（3）的辣椒素类物质可以通过使用酶而不使用脱水剂，在不使用溶剂或低极性溶剂的情况下，通过将公式（1）的脂肪酸与公式（2）的羟甲基酚酯化反应，高产率地、短时间内方便地制备。公式（4）代表的脂肪酸的添加对于稳定公式（3）的酯化物也是有效的。其中每个符号如规范中所定义。
• Pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent
  申请人：Propanc Pty Ltd

  公开号：US10350239B2

  公开（公告）日：2019-07-16

  The present invention generally relates to pharmaceutical compositions containing a protease proenzyme and use thereof for treating cancer. The pharmaceutical compositions are directed to compositions comprising a protease proenzyme and an active agent, the composition being capable of providing a multi-functional approach for treating cancer. The pharmaceutical compositions are also directed to compositions comprising a first and a second protease proenzyme capable of activation at or near a surface of a tumor cell to enhance cell-to-cell adhesion of tumor cells, effect proteolysis of tumor cells, or induce tumor cell apoptosis, differentiation or immunorecognition, wherein the first protease proenzyme is chymotrypsinogen and the second protease proenzyme is trypsinogen. The pharmaceutical compositions are also directed to compositions comprising a first and second active agent each capable of inducing intracellular activity in tumor cells.

  本发明一般涉及含有蛋白酶原的药物组合物及其治疗癌症的用途。这些药物组合物涉及包含蛋白酶原和活性剂的组合物，该组合物能够提供治疗癌症的多功能方法。本发明的药物组合物还涉及包含第一和第二蛋白酶原的组合物，第一和第二蛋白酶原能够在肿瘤细胞表面或其附近活化，以增强肿瘤细胞的细胞间粘附性，影响肿瘤细胞的蛋白分解，或诱导肿瘤细胞凋亡、分化或免疫认知，其中第一蛋白酶原是糜蛋白酶原，第二蛋白酶原是胰蛋白酶原。该药物组合物还涉及包含第一和第二活性剂的组合物，每种活性剂都能诱导肿瘤细胞的细胞内活性。
• PRODUCTION METHOD OF CAPSINOID BY DEHYDRATING CONDENSATION AND STABILIZING METHOD OF CAPSINOID
  申请人：Ajinomoto Co., Inc.

  公开号：EP1853547B1

  公开（公告）日：2014-11-12