5,7-dimethylphthalazine | 78032-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5,7-dimethylphthalazine
• CAS: 78032-06-1
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.203
• InChiKey: HMEGOYMIPUGFHF-UHFFFAOYSA-N

物化性质

• 熔点：
  105-106 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• 沸点：
  350.1±11.0 °C(Predicted)
• 密度：
  1.109±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1E,2E)-1,2-bis(2,4-dimethylbenzylidene)hydrazine 生成 5,7-dimethylphthalazine
  参考文献：
  名称：

  ROBEV, S. K.

  摘要：

  DOI：

文献信息

• Phthalazine derivatives from aromatic aldazines
  作者：Stefan K. Robev

  DOI：10.1016/0040-4039(81)80093-7

  日期：1981.1

  A Lewis acid mediated synthesis of phthalazine derivatives II and III from aromatic aldazines I is reported.

  报道了路易斯酸介导的由芳族醛嗪I合成邻苯二嗪衍生物II和III的过程。
• CARBAZOLE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20170077419A1

  公开（公告）日：2017-03-16

  A carbazole-based compound and an organic light-emitting device including the same, wherein the carbazole-based compound is represented by Formula 1: In Formula 1, at least one selected from R 1 to R 9 may be a group represented by Formula 2, and rings A and B are each selected from a phenyl or a naphthyl. When at least one compound represented by Formula 1 is included as a green fluorescent host in an emission layer of an organic light-emitting device, the example OLEDs had improved efficiencies and longer lifespans compared to the organic light-emitting devices of the related art.

  一种基于咔唑的化合物和包括该化合物的有机发光器件，其中基于咔唑的化合物由式1表示：在式1中，R1至R9中至少有一个可是由式2表示的基团，环A和环B分别选自苯基或萘基。当至少一种由式1表示的化合物作为有机发光器件的发射层中的绿色荧光主体时，示例OLED相对于相关技术的有机发光器件具有改善的效率和更长的寿命。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2765187A1

  公开（公告）日：2014-08-13

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.

  提供了一种诱导多能干细胞产生巨核细胞和/或血小板的制剂，该制剂可用于治疗伴随血小板减少的疾病。 一种生产巨核细胞和/或血小板的方法，包括在多能干细胞产生的囊状结构中将造血祖细胞从隔细胞中分离出来，并在由式（I）代表的化合物（其中R1至R7、W、X、Y、Z、Ar1和n如描述中所定义）存在下体内外培养造血祖细胞，使其分化成巨核细胞和/或血小板。
• Carbazole-based compound and organic light-emitting device including the same
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US10249830B2

  公开（公告）日：2019-04-02

  A carbazole-based compound and an organic light-emitting device including the same, wherein the carbazole-based compound is represented by Formula 1: wherein in Formula 1, at least one selected from R1 to R9 may be a group represented by Formula 2, and rings A and B are each selected from a phenyl or a naphthyl. When at least one compound represented by Formula 1 is included as a green fluorescent host in an emission layer of an organic light-emitting device, the example OLEDs may have improved efficiencies and longer lifespans compared to the organic light-emitting devices of the related art.

  一种咔唑基化合物和包括该化合物的有机发光器件，其中咔唑基化合物由式 1 表示： 其中，在式 1 中，R1 至 R9 中至少有一个可以是由式 2 所代表的基团，且环 A 和环 B 分别选自苯基或萘基。当至少一种由式 1 代表的化合物作为绿色荧光宿主被包含在有机发光器件的发射层中时，与相关技术的有机发光器件相比，本发明实例的有机发光器件可能具有更高的效率和更长的寿命。