(E)-3-(2,4-dimethylphenyl)prop-2-enal | 99668-10-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醛
• 英文名称: (E)-3-(2,4-dimethylphenyl)prop-2-enal
• 英文别名: (E)-3-(2,4-dimethylphenyl)acrylaldehyde；2,4-dimethyl-cinnamaldehyde；2,4-Dimethyl-zimtaldehyd；3-(2,4-Dimethylphenyl)prop-2-enal
• CAS: 99668-10-7
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: FNVRKBJDPCPUQF-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-3-(2,4-dimethylphenyl)prop-2-enal 生成 2,4-dimethyl-cinnamaldehyde-semicarbazone
  参考文献：
  名称：

  Bert; Dorier, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1930, vol. 191, p. 332

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二甲基苯甲醛 在 盐酸 、 三氟化硼乙醚 作用下， 以 甲醇 、 水 为溶剂， 反应 9.5h， 生成 (E)-3-(2,4-dimethylphenyl)prop-2-enal
  参考文献：
  名称：

  一种氨基酸衍生物、饲用组合物及其应用

  摘要：

  本申请提供一种氨基酸衍生物、饲用组合物及其应用，属于动物饲料添加剂技术领域。氨基酸衍生物为结构如式(Ⅰ)所示的化合物、其立体异构体、其互变异构体、其溶剂合物、其代谢产物、其饲料上可接受的盐或其前药。式(Ⅰ)为：式(Ⅰ)中，Z为C1‑C3亚烷基。X为结构如式(Ⅱ)所示的吲哚环基。式(Ⅱ)为：Y为结构如式(Ⅲ)所示的苯基。式(Ⅲ)为：此化合物用来作为动物饲料添加剂，能够促进动物的生长，提高饲料报酬。

  公开号：

  CN111072545A

文献信息

• [EN] NOVEL SPIROINDOLINE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SPIROINDOLINE
  申请人：INTERVET INT BV

  公开号：WO2013017678A1

  公开（公告）日：2013-02-07

  This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及一种新型螺环吲哚烷化合物，通式为(I)，通常用作药物，更具体地用作动物药物。该药物可用于治疗蠕虫感染和寄生虫病的治疗，比如由蠕虫感染引起的寄生虫病。本发明还涉及利用这些化合物制备药物和治疗方案，包括将这些化合物用于需要治疗的动物。此外，本发明还涉及所述化合物的制备。此外，本发明还涉及包含这些化合物的药物组合物和工具包。
• NOVEL SPIROINDOLINE COMPOUNDS
  申请人：Chassaing Christophe Pierre Alain

  公开号：US20140163056A1

  公开（公告）日：2014-06-12

  This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及一种新的螺环吲哚类化合物，其化学式为(I)，通常作为药物使用，更具体地作为动物药物使用。该药物可以优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及利用该化合物制备药物和治疗方法，包括将该化合物用于需要治疗的动物的治疗。本发明还涉及所述化合物的制备方法。此外，本发明还涉及包含该化合物的药物组合物和配套工具。
• Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups
  作者：Xing-Long Zhang、Gao-Fei Pan、Xue-Qing Zhu、Rui-Li Guo、Ya-Ru Gao、Yong-Qiang Wang

  DOI：10.1021/acs.orglett.9b00695

  日期：2019.4.19

  An unprecedented cross-dehydrogenative-coupling (CDC) reaction of saturated aldehyde beta-C-H with arenes to form cinnamaldehydes via the cleavages of four C-H bonds has been developed. The reaction possesses complete E-stereoselectivity for the C = C double bond. The protocol is featured by atom and step economy, mild reaction conditions, and convenient operation.
• Phenyl β-Methoxyacrylates:  A New Antimalarial Pharmacophore
  作者：Jawad Alzeer、Jacques Chollet、Ingrid Heinze-Krauss、Christian Hubschwerlen、Hugues Matile、Robert G. Ridley

  DOI：10.1021/jm990002y

  日期：2000.2.1

  Phenyl beta-methoxyacrylates, linked to an aromatic ring via an olefinic bridge, have been identified as novel, potentially inexpensive, antimalarial agents. The compounds are believed to exert their activity by inhibition of mitochondrial electron transport at the cytochrome bc(1) complex. A series of compounds have been synthesized to define structure-activity relationships affecting antimalarial activity. It was found that the beta-methoxyacrylate was required ortho to the linker and the optimal bridge was (E,E)-butadiene, Compounds in which the second aromatic ring was ortho-substituted or ortho,para-disubstituted gave optimal potency. Several compounds were identified with potency that is superior to that of chloroquine both in culture and in a murine malaria model.
• HOFFMAN, W. F.;ALBERTS, A. W.;CRAGOE, E. J. ,, JR.;DEANA, A. A.;EVANS, B.+, J. MED. CHEM., 1986, 29, N 2, 159-169
  作者：HOFFMAN, W. F.、ALBERTS, A. W.、CRAGOE, E. J. ,, JR.、DEANA, A. A.、EVANS, B.+

  DOI：——

  日期：——