N-(2-carbamoylphenyl)naphthalene-2-carboxamide | 413573-66-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-carbamoylphenyl)naphthalene-2-carboxamide
• CAS: 413573-66-7
• 化学式: C₁₈H₁₄N₂O₂
• 分子量: 290.321
• InChiKey: MIHAZYWIRKMHBR-UHFFFAOYSA-N

物化性质

• 溶解度：
  <0.3 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-carbamoylphenyl)naphthalene-2-carboxamide 在 双氧水 、 sodium ethanolate 作用下， 以65%的产率得到2-(naphthalen-2-yl)quinazolin-4(3H)-one
  参考文献：
  名称：

  Identification of chemokine receptor CCR4 antagonist

  摘要：

  The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.084
• 作为产物：
  描述：

  2-氨基苯甲酰胺 、 2-萘甲酸 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到N-(2-carbamoylphenyl)naphthalene-2-carboxamide
  参考文献：
  名称：

  Identification of chemokine receptor CCR4 antagonist

  摘要：

  The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.084

文献信息

• [EN] STREPTOCOCCUS MUTANS GLUCOSYL TRANSFERASE INHIBITORS FOR DENTAL CARIES THERAPY<br/>[FR] INHIBITEURS DE GLUCOSYLE TRANSFÉRASE DE STREPTOCOCCUS MUTANS POUR LA THÉRAPIE DES CARIES DENTAIRES
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2019195430A1

  公开（公告）日：2019-10-10

  The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.

  本发明涉及通过抑制葡萄糖基转移酶(Gtf)来抑制链球菌生物膜形成的方法。提供了用于抑制链球菌生物膜形成的化合物、组合物和方法，以及用于预防、抑制和/或治疗龋齿形成的方法，以及用于识别能够预防、抑制和/或治疗龋齿形成的化合物的方法。
• Honeybee Repellents and Uses Thereof
  申请人：Inscent, Inc.

  公开号：US20140329674A1

  公开（公告）日：2014-11-06

  The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.
• STREPTOCOCCUS MUTANS GLUCOSYL TRANSFERASE INHIBITORS FOR DENTAL CARIES THERAPY
  申请人：UAB Research Foundation

  公开号：US20210115007A1

  公开（公告）日：2021-04-22

  The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.
• US9357781B2
  申请人：——

  公开号：US9357781B2

  公开（公告）日：2016-06-07
• US9796676B2
  申请人：——

  公开号：US9796676B2

  公开（公告）日：2017-10-24