3-phenylquinoxaline-6-carboxamide | 403620-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-phenylquinoxaline-6-carboxamide
• CAS: 403620-43-9
• 化学式: C₁₅H₁₁N₃O
• 分子量: 249.272
• InChiKey: ZQZMGYNFRKRYRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟-3-硝基苯甲酸 、 2-溴苯乙酮 生成 3-phenylquinoxaline-6-carboxamide 、 2-Phenyl-quinoxaline-6-carboxylic acid amide
  参考文献：
  名称：

  Solid-phase synthesis of quinoxalines on SynPhase™ Lanterns

  摘要：

  A convenient and straightforward solid-phase synthesis of quinoxalines is described. A polymer-bound o-phenylenediamine was reacted with alpha -bromoketones in DMF at 60 degreesC to give quinoxalines in good purity and yield after TFA cleavage. The quinoxalines were presumably formed via an initial nucleophilic substitution, followed by subsequent cyclization-oxidation. A small library of ten quinoxalines was prepared on SynPhase (TM) Lanterns using this simple one-pot procedure. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01733-6

文献信息

• [EN] QUINOXALINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS À BASE DE QUINOXALINE ET LEURS UTILISATIONS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2015161142A1

  公开（公告）日：2015-10-22

  This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R4, Rq, o, RA, and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease.

  这项发明提供了公式I及其子集的化合物：其中T、J、R、R4、Rq、o、RA和RB以及其子集如规范中所述。这些化合物是NAMPT的抑制剂，因此可用于治疗癌症、炎症性疾病或T细胞介导的自身免疫疾病。
• QUINOXALINE COMPOUNDS AND USES THEREOF
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：EP3131881A1

  公开（公告）日：2017-02-22
• Solid-phase synthesis of quinoxalines on SynPhase™ Lanterns
  作者：Zemin Wu、Nicholas J Ede

  DOI：10.1016/s0040-4039(01)01733-6

  日期：2001.11

  A convenient and straightforward solid-phase synthesis of quinoxalines is described. A polymer-bound o-phenylenediamine was reacted with alpha -bromoketones in DMF at 60 degreesC to give quinoxalines in good purity and yield after TFA cleavage. The quinoxalines were presumably formed via an initial nucleophilic substitution, followed by subsequent cyclization-oxidation. A small library of ten quinoxalines was prepared on SynPhase (TM) Lanterns using this simple one-pot procedure. (C) 2001 Elsevier Science Ltd. All rights reserved.