2-(十一烷基氨基)乙醇 | 14206-60-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(十一烷基氨基)乙醇
• 英文名称: 2-(undecylamino)ethanol
• 英文别名: 2-undecylamino-ethanol；N-Undecyl-β-amino-ethanol；N-Undecyl-β-aminoethanol
• CAS: 14206-60-1
• 化学式: C₁₃H₂₉NO
• 分子量: 215.379
• InChiKey: BZMGMGOJSGJEAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(十一烷基氨基)乙醇 、 2-氯乙氧基乙醇 生成 2-[2-(2-hydroxyethoxy)ethyl-undecylamino]ethanol
  参考文献：
  名称：

  WEDLER C.; HAAGE K.; HERBST M.; TISCHER H.; KNOPE E., ABH. AKAD. WISS. DDR. ABT. MATH., NATURWISS., TECHN.,(1986) N 1N, 589-594

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氯十一烷 、 C.I.酸性橙108 以 乙醇 为溶剂， 反应 24.0h， 生成 2-(十一烷基氨基)乙醇
  参考文献：
  名称：

  Diamine derivative anti-Trichomonas vaginalis and anti-Tritrichomonas foetus activities by effect on polyamine metabolism

  摘要：

  Human and bovine trichomoniasis are sexually transmitted diseases (STD) caused by Trichomonas vaginalis and Tritrichomonas foetus, respectively. Human trichomoniasis is the most common non-viral STD in the world and bovine trichomoniasis causes significant economic losses to breeders. Considering the significant impact of the infections caused by these protozoa and the treatment failures, the search for new therapeutic alternatives becomes crucial. In this study the effect of diamines and amino alcohols in the in vitro viability of trichomonads was evaluated. Screening demonstrated the high activity of diamine 4 against these protozoa. Although cytotoxicity against HMVII cell line and slight hemolysis were observed in vitro, the compound showed no toxic effect on the Galleria mellonella in vivo model. Importantly, diamine 4 was active against both trichomonads species at 6 h and 24 h of incubation, and these effects was reverted by putrescine, a polyamine, suggesting competition for the same metabolic pathway. These findings indicate that the mechanism of action of diamine 4 is through the polyamine metabolism, a pathway distinct from that presented by metronidazole, the drug usually used to treat trichomoniasis and to which resistance is widely reported. These data demonstrate the importance of diamines as potential novel candidates as anti-T. vaginalis and anti-T. foetus agents.

  DOI：

  10.1016/j.biopha.2017.09.007

文献信息

• Substituted aminoalkanol phospholipids
  申请人：A. Nattermann & Cie GmbH

  公开号：US04565659A1

  公开（公告）日：1986-01-21

  The invention concerns new substituted aminoalkanol phospholipids of the general Formula I ##STR1## and methods for the treatment of humans suffering from high blood-pressure (hypertension), from inflammatory illnesses, from tumors and/or atherosclerosis by administering medicaments containing such a compound as well as methods for plant protections.

  这项发明涉及一种新的取代氨基烷醇磷脂类化合物，其一般化学式如下所示，并提供了一种治疗高血压、炎症性疾病、肿瘤和/或动脉粥样硬化的方法，该方法是通过给患者使用含有这种化合物的药物，并提供了一种植物保护的方法。
• Substituierte Aminoalkanolphospholipide und Verfahren zu ihrer Herstellung
  申请人：A. Nattermann & Cie. GmbH

  公开号：EP0107120A1

  公开（公告）日：1984-05-02

  Die Erfindung betrifft neue substituierte Aminoalkanolphospholipide der allgemeinen Formel 1 und Verfahren zu ihrer Herstellung. Die Verbindungen zeigen starke biologische Aktivität und können z.B. in Arzneimitteln und im Pflanzenschutz eingesetzt werden. Sie besitzen z.B. blutdrucksenkende, entzündungshemmende. tumorhemmende und antiatherosklerotische Eigenschaften.

  本发明涉及通式 1 的新型取代氨基烷醇磷脂及其制备工艺。 及其制备工艺。这些化合物具有很强的生物活性，可用于制药和植物保护等领域。例如，它们具有抗高血压、抗炎、抗肿瘤和抗动脉粥样硬化的特性。
• Thermoplastic elastomer composition
  申请人：THE YOKOHAMA RUBBER CO., LTD.

  公开号：EP1695987A1

  公开（公告）日：2006-08-30

  Disclosed is a thermoplastic elastomer composition including a thermoplastic elastomer (A) having a side chain having at least one member selected from the group consisting of imino group, nitrogen-containing heterocycle and covalent crosslink site, and a carbonyl-containing group, and an ethylene-propylene copolymer (B) comprising propylene block and ethylene-propylene block. The thermoplastic elastomer of the present invention exhibits excellent high temperature flowability and mechanical strength while retaining its excellent flexibility.

  本发明公开了一种热塑性弹性体组合物，包括一种热塑性弹性体（A），其侧链至少有一个成员选自亚胺基、含氮杂环和共价交联位点以及含羰基组成的组，以及一种乙烯-丙烯共聚物（B），该共聚物包括丙烯嵌段和乙烯-丙烯嵌段。本发明的热塑性弹性体具有极佳的高温流动性和机械强度，同时还能保持良好的柔韧性。
• METHOD FOR ADHESIVE-BONDING VULCANIZED RUBBER COMPOSITIONS BY THE USE OF THERMOPLASTIC ELASTOMER COMPOSITIONS
  申请人：THE YOKOHAMA RUBBER CO., LTD.

  公开号：EP1724318A1

  公开（公告）日：2006-11-22

  An object of the present invention is to provide a method of adhering a vulcanized rubber composition using a thermoplastic elastomer composition capable of maintaining recycling property and excellent in adhesiveness. The above object is achieved by the following method of adhering a vulcanized rubber composition. A method of adhering a vulcanized rubber composition of the present invention is a method of adhering a vulcanized rubber composition using a thermoplastic elastomer composition. The thermoplastic elastomer composition contains a thermoplastic elastomer and a filler. The thermoplastic elastomer has: a monomer unit forming a rubber component of the vulcanized rubber composition on at least part of its main chain; and a side chain containing a structure represented by a predetermined structural formula, the structure having a carbonyl group and an imino group, and/or a nitrogen-containing heterocyclic ring. The method includes adhering a first member and a second member each composed of the vulcanized rubber composition through the thermoplastic elastomer composition.

  本发明的目的是提供一种使用热塑性弹性体组合物粘合硫化橡胶组合物的方法，该热塑性弹性体组合物能够保持回收性能和优异的粘合性。上述目的通过以下硫化橡胶组合物的粘合方法来实现。本发明的硫化橡胶组合物粘合方法是一种使用热塑性弹性体组合物粘合硫化橡胶组合物的方法。热塑性弹性体组合物包含热塑性弹性体和填料。热塑性弹性体具有：在其主链的至少一部分上构成硫化橡胶组合物的橡胶成分的单体单元；以及含有由预定结构式表示的结构的侧链，该结构具有一个羰基和一个亚氨基，和/或一个含氮杂环。该方法包括通过热塑性弹性体组合物粘附由硫化橡胶组合物构成的第一构件和第二构件。
• LUBRICATING OIL COMPOSITION, AND SLIDING MECHANISM USING LUBRICATING OIL COMPOSITION
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP2826845A1

  公开（公告）日：2015-01-21

  Disclosed is a lubricating oil composition for low-friction sliding materials, which is used in a sliding mechanism where a DLC film containing hydrogen in an amount of from 5 atom% to 50 atom% is formed on at least one sliding surface. The lubricating oil composition contains, in the lubricant base oil therein and based on the total amount of the composition, (A) an organic zinc dithiophosphate in an amount of from 0.005% by mass to 0.12% by mass in terms of the phosphorus concentration therein, (B) an amine-based friction-reducing agent in an amount of from 0.05% by mass to 5.0% by mass, and (C) an alkaline earth metal salicylate-based detergent and/or an alkaline earth metal sulfonate-based detergent in an amount of from 0.05% by mass to 0.5% by mass in terms of the alkaline earth metal concentration therein, wherein the component (A) contains, based on the total amount of the composition, a zinc primary dialkyldithiophosphate in an amount of from 0.005% by mass to 0.05% by mass in terms of the phosphorus concentration therein.

  本发明公开了一种用于低摩擦滑动材料的润滑油组合物，该组合物用于在至少一个滑动表面上形成含氢量为 5 原子％至 50 原子％的 DLC 膜的滑动机构中。该润滑油组合物在其中的润滑油基础油中，根据组合物的总量，含有 (A) 有机二硫代磷酸锌，以其中的磷浓度计，含量为 0.005% （质量百分比）至 0.12% （质量百分比）；(B) 基于胺的减摩剂，含量为 0.05% （质量百分比）至 5.(C) 碱土金属水杨酸酯类洗涤剂和/或碱土金属磺酸盐类洗涤剂，以其中碱土金属的浓度计，其用量为 0.05% (质量) 至 0.5% (质量)，其中组分 (A) 含有以组合物总量计，以其中磷的浓度计，其用量为 0.005% (质量) 至 0.05% (质量)的伯基二烷基二硫代磷酸锌。