rosmadial | 85514-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: rosmadial
• 英文别名: (1'S,3R)-7-hydroxy-2',2'-dimethyl-2-oxo-6-propan-2-ylspiro[1-benzofuran-3,6'-cyclohexane]-1',4-dicarbaldehyde
• CAS: 85514-31-4
• 化学式: C₂₀H₂₄O₅
• 分子量: 344.408
• InChiKey: JBWRHBJFAVSAMJ-VBKZILBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  rosmadial 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 methyl rosmadial
  参考文献：
  名称：

  Nakatani, Nobuji; Inatani, Reiko, Agricultural and Biological Chemistry, 1983, vol. 47, # 2, p. 353 - 358

  摘要：

  DOI：

文献信息

• Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease
  申请人：Kim S. H. L. Darrick

  公开号：US20070003641A1

  公开（公告）日：2007-01-04

  Disclosed are combinations of natural and synthetic turmeric, ginger, ginko biloba, sage, and rosemary compounds suitable for treatment of beta-amyloid-disease induced disease that have synergistic anti-βA peptide effects when members of the five groups of compounds are combined. Suitable members of the compounds include both natural compounds derived from extracts of each of Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., or Rosmarinus sp. as well as synthetic homologues and analogues of such natural compounds. Sage and rosemary derived compounds suitable alone for treatment of beta-amyloid induced disease is also described.
• US7728043B2
  申请人：——

  公开号：US7728043B2

  公开（公告）日：2010-06-01
• Nakatani, Nobuji; Inatani, Reiko, Agricultural and Biological Chemistry, 1983, vol. 47, # 2, p. 353 - 358
  作者：Nakatani, Nobuji、Inatani, Reiko

  DOI：——

  日期：——