(E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2H-chromen-3-yl)prop-2-en-1-one | 1229681-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2H-chromen-3-yl)prop-2-en-1-one
• CAS: 1229681-49-5
• 化学式: C₁₉H₁₄Cl₂O₃
• 分子量: 361.224
• InChiKey: ROWYKYIMLFOYTR-QHHAFSJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基苯酚 在 potassium carbonate 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 乙醇 、 水 为溶剂， 反应 8.0h， 生成 (E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2H-chromen-3-yl)prop-2-en-1-one
  参考文献：
  名称：

  Chromene-Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity

  摘要：

  Two types of regioisomeric chromene‐based chalcones namely, 1‐(6‐methoxy‐2H‐chromen‐3‐yl)‐3‐phenylpropen‐1‐ones and 3‐(6‐methoxy‐2H‐chromen‐3‐yl)‐1‐phenylpropen‐1‐ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major. The obtained results from in vitro biological assays indicated that chloro‐substituted 1‐(6‐methoxy‐2H‐chromen‐3‐yl)‐3‐phenylpropen‐1‐ones exhibited excellent activity against Leishmania major at non‐cytotoxic concentrations.

  DOI：

  10.1111/j.1747-0285.2010.00959.x

文献信息

• Chromene-Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity
  作者：Alireza Foroumadi、Saeed Emami、Maedeh Sorkhi、Maryam Nakhjiri、Zohreh Nazarian、Samaneh Heydari、Sussan K. Ardestani、Fatemeh Poorrajab、Abbas Shafiee

  DOI：10.1111/j.1747-0285.2010.00959.x

  日期：——

  Two types of regioisomeric chromene‐based chalcones namely, 1‐(6‐methoxy‐2H‐chromen‐3‐yl)‐3‐phenylpropen‐1‐ones and 3‐(6‐methoxy‐2H‐chromen‐3‐yl)‐1‐phenylpropen‐1‐ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major. The obtained results from in vitro biological assays indicated that chloro‐substituted 1‐(6‐methoxy‐2H‐chromen‐3‐yl)‐3‐phenylpropen‐1‐ones exhibited excellent activity against Leishmania major at non‐cytotoxic concentrations.