chloromethyl(cyclopropyl)dimethylsilane | 54690-67-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: chloromethyl(cyclopropyl)dimethylsilane
• 英文别名: (Chlormethyl-dimethyl-silyl)-cyclopropan；Chlormethyl-cyclopropyl-dimethyl-silan；(Chloromethyl)(cyclopropyl)dimethylsilane；chloromethyl-cyclopropyl-dimethylsilane
• CAS: 54690-67-4
• 化学式: C₆H₁₃ClSi
• mdl: MFCD19233027
• 分子量: 148.708
• InChiKey: DQUVMKCUQHAVMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  chloromethyl(cyclopropyl)dimethylsilane 在 4-二甲氨基吡啶 、 lithium hydroxide 、 N,N'-二环己基碳二亚胺 、 苯甲醇 作用下， 以 二氯甲烷 为溶剂， 生成 benzyl 4-cyclopropyl(dimethyl)silyl-3-cyanobutanoate
  参考文献：
  名称：

  SILICON-CONTAINING CARBOXYLIC ACID DERIVATIVE

  摘要：

  化合物的化学式为（I）[其中至少一个R1，R2和R3代表环烷基，其余代表线性或支链烷基；n代表0或1；R4代表氨基或—（CX2）m—COOH（m代表0至3，X代表氢原子）；R5代表—（CY2）p—COOR6（p代表0至3，Y代表氢原子，R6代表氢原子或烷基）]或其盐。

  公开号：

  US20150232487A1
• 作为产物：
  描述：

  cyclopropyltrimethylsilane 在 氯 作用下， 生成 chloromethyl(cyclopropyl)dimethylsilane
  参考文献：
  名称：

  Mironov,V.F. et al., Doklady Chemistry, 1975, vol. 222, p. 322 - 325

  摘要：

  DOI：

文献信息

• Fluoride ion induced rearrangements of chloromethyl-substituted silanes: carbanionic character of groups undergoing migration
  作者：Robert Damrauer、Stephen E. Danahey、Vernon E. Yost

  DOI：10.1021/ja00336a060

  日期：1984.11

  On montre que le chloromethyl trimethyl silane reagit avec KF ou CsF en presence de 18-crown-6 dans un solvant aromatique pour conduire exclusivement au dimethyl ethyl fluoro silane. Mecanisme

  在 montre que le 氯甲基三甲基硅烷反应剂 avec KF 或 CsF 上存在 de 18-crown-6 dans 非溶剂芳香剂倾倒 au 二甲基乙基氟硅烷。机制
• Silicon-Containing GABA Derivatives, Silagaba Compounds, as Orally Effective Agents for Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects
  作者：Hiroshi Fukasawa、Hideaki Muratake、Ai Ito、Hideyuki Suzuki、Yohei Amano、Marina Nagae、Kiyoshi Sugiyama、Koichi Shudo

  DOI：10.1021/cn500053d

  日期：2014.7.16

  Neuropathic pain is a chronic condition resulting from neuronal damage. Pregabalin, the (S)-isomer of 3-isobutyl-gamma-aminobutyric acid (GABA), is widely used to treat neuropathic pain, despite the occurrence of central nervous system (CNS)-related side effects such as dizziness and somnolence. Here we describe the pharmacology of novel GABA derivatives containing silicon-carbon bonds, silagaba compounds. Silagaba131, 132, and 161 showed pregabalin-like analgesic activities in animal models of neuropathic pain, but in contrast to pregabalin they did not impair neuromuscular coordination in rotarod tests. Pharmacokinetic studies showed that brain exposure to silagaba compounds was lower than that to pregabalin. Surprisingly, despite their potent analgesic action in vivo, silagaba compounds showed only weak binding to alpha 2-delta protein. These compounds may be useful to study mechanisms of neuropathic pain. Our results also indicate that silagaba132 and 161 are candidates for orally effective treatment of neuropathic pain without CNS-related side effects.
• Mironov,V.F. et al., Doklady Chemistry, 1975, vol. 222, p. 322 - 325
  作者：Mironov,V.F. et al.

  DOI：——

  日期：——
• SILICON-CONTAINING CARBOXYLIC ACID DERIVATIVE
  申请人：KEMPHYS LTD.

  公开号：US20150232487A1

  公开（公告）日：2015-08-20

  A compound represented by the formula (I) [at least one of R 1 , R 2 , and R 3 represents a cyclic alkyl group, the remaining represents a linear or branched alkyl group; n represents 0 or 1; R 4 represents an amino group or —(CX 2 ) m —COOH (m represents 0 to 3, and X represents hydrogen atom); and R 5 represents —(CY 2 ) p —COOR 6 (p represents 0 to 3, Y represents hydrogen atom, and R 6 represents hydrogen atom or an alkyl group)], or a salt thereof.

  化合物的化学式为（I）[其中至少一个R1，R2和R3代表环烷基，其余代表线性或支链烷基；n代表0或1；R4代表氨基或—（CX2）m—COOH（m代表0至3，X代表氢原子）；R5代表—（CY2）p—COOR6（p代表0至3，Y代表氢原子，R6代表氢原子或烷基）]或其盐。