2-(甲基氨基)-2-甲基丙腈 | 2273-39-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(甲基氨基)-2-甲基丙腈
• 英文名称: 2-methylamino-2-methylpropanenitrile
• 英文别名: α-methylaminoisobutyronitrile；2-methyl-2-methylamino-propionitrile；2-Methyl-2-(methylamino)propanenitrile
• CAS: 2273-39-4
• 化学式: C₅H₁₀N₂
• mdl: MFCD03208517
• 分子量: 98.1478
• InChiKey: NKQVYJRZBVRXRU-UHFFFAOYSA-N

物化性质

• 沸点：
  59 °C(Press: 20 Torr)
• 密度：
  0.8698 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  2-(甲基氨基)-2-甲基丙腈 在 盐酸 作用下， 生成 α-[(3-cyano-propyl)-methyl-amino]-isobutyric acid ethyl ester
  参考文献：
  名称：

  Rearrangement of α-Aminoketones during Clemmensen Reduction. V. Influence of Alkyl Substitution on the α-Carbon^1,2,3

  摘要：

  DOI：

  10.1021/ja01164a087
• 作为产物：
  描述：

  imino-5 trimethyl-3,4,4 thiazolidine thione-2 以 水 为溶剂， 生成 2-(甲基氨基)-2-甲基丙腈
  参考文献：
  名称：

  Taillades, Jacques; Rousset, Alain; Lasperas, Monique, Bulletin de la Societe Chimique de France, 1986, # 4, p. 650 - 658

  摘要：

  DOI：

文献信息

• [EN] TARGETED BIFUNCTIONAL DEGRADERS<br/>[FR] AGENTS DE DÉGRADATION BIFONCTIONNELS CIBLÉS
  申请人：UNIV YALE

  公开号：WO2021072269A1

  公开（公告）日：2021-04-15

  The present invention provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present invention provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the invention to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF.

  本发明在一个方面提供了可以用来促进或增强降解某些循环蛋白的双功能化合物。在另一个方面，本发明提供了可以用来促进或增强降解某些自身抗体的双功能化合物。在某些实施方式中，治疗或管理疾病和/或疾病需要降解、去除或减少受试者体内循环蛋白或自身抗体的浓度。因此，在某些实施方式中，将本发明的化合物给予受试者可去除或减少循环蛋白或自身抗体的循环浓度，从而治疗、改善或预防疾病和/或疾病。在某些实施方式中，循环蛋白是TNF。
• Preparation, 1H and 13C NMR Spectra of Substituted 2-Benzoylaminocarboxamides
  作者：Miloš Sedlák、Aleš Halama、Jaromír Kaválek、Vladimír Macháček、Vojeslav Štěrba

  DOI：10.1135/cccc19950150

  日期：——

  A new type of herbicides based on imidazolinones has been introduced into agriculture under commercial names of Arsenal, Pursuit, Scepter, Assert etc. by American Cyanamid Company since 1983. These compounds destroy diocotyledonous weeds and are almost nontoxic for mammals and fish (LD₅₀ rat - 500 mg/kg, LD₅₀ trout - 300 mg/kg) and nonmutagenic according to the AMES test. The aim of the present work is to synthesize substituted 2-benzoylaminocarboxamides as starting materials for preparation of imidazolinones and potential biologically active substances (Formulae I - III).

  一种基于咪唑啉酮的新型除草剂自1983年起由美国赛诺美公司推出，商业名称为Arsenal、Pursuit、Scepter、Assert等。这些化合物能够消灭双子叶杂草，对哺乳动物和鱼类几乎无毒（LD₅₀ 大鼠 - 500 毫克/千克，LD₅₀ 鳟鱼 - 300 毫克/千克），根据AMES试验结果，这些化合物不具有致突变性。本研究的目的是合成取代的2-苯甲酰氨基羧酰胺，作为制备咪唑啉酮和潜在生物活性物质的起始原料（式 I - III）。
• Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use
  申请人：——

  公开号：US20030225147A1

  公开（公告）日：2003-12-04

  Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. 1 These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

  氨基噻唑化合物与单取代/双取代苯甲酰胺的结构由式(I)表示，并描述了它们的药学上可接受的盐、药学上可接受的前药、药学上活性代谢物以及所述代谢物的药学上可接受的盐。 这些药物调节和/或抑制细胞增殖和蛋白激酶活性，并可用作治疗恶性肿瘤和其他疾病的药物。
• PYRAZOLAMIDE COMPOUND HAVING INSECTICIDAL ACTIVITY AND USE THEREOF
  申请人：JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD.

  公开号：US20200329707A1

  公开（公告）日：2020-10-22

  The present invention discloses a pyrazolamide compound of General Formula I having an insecticidal activity and an intermediate of General Formula II used to preparing the compound of General Formula I, wherein R 1 is selected from chloro or CN, R 2 is selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or C 1 -C 5 alkoxyalkyl, R 3 is selected from halo or C 1 -C 3 haloalkyl, R 4 is selected from halo, and R 5 is selected from H or halo. Compared with the compounds in the prior art, the compound of General Formula I of the present invention has a higher activity at a low concentration. This reduces the amount of the compound used and the residue of the compound in farmland, and is thus environmentally friendly.

  本发明公开了一种具有杀虫活性的一般式I的吡唑酰胺化合物，以及用于制备一般式I化合物的一般式II的中间体，其中R1选自氯或CN，R2选自H、C1-C3烷基、C1-C3卤代烷基或C1-C5烷氧基烷基，R3选自卤或C1-C3卤代烷基，R4选自卤，R5选自H或卤。与先前技术中的化合物相比，本发明的一般式I化合物在低浓度下具有更高的活性。这降低了化合物的使用量和在农田中的残留量，因此对环境更友好。
• N-ALKYL-N-CYANOALKYLBENZAMIDE COMPOUND AND USE THEREOF
  申请人：JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD.

  公开号：US20210009554A1

  公开（公告）日：2021-01-14

  The present invention discloses an N-alkyl-N-cyanoalkylbenzamide compound of General Formula I, an intermediate of General Formula II used to prepare the compound, wherein R 1 is selected from halo or C 1 -C 3 alkyl; R 2 is selected from halo or CN; R 3 is selected from halo, or C 1 -C 3 haloalkyl; R 4 is selected from halo; R 5 is selected from H or halo; R 6 is selected from C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or C 1 -C 5 alkoxyalkyl; R 7 is selected from C 1 -C 5 alkyl; and R 8 is selected from hydrogen or C 1 -C 5 alkyl. Compared with the compounds in the prior art, the compound of General Formula I has a higher activity at a low concentration. Particularly, the compound of the present invention still has 60% or higher of the insecticidal activity at a concentration below 1 ppm. This greatly reduces the amount of the compound used and the residue of the compound in farmland, and is thus environmentally friendly.

  本发明公开了一种一般式I的N-烷基-N-氰基烷基苯甲酰胺化合物，一种用于制备该化合物的一般式II的中间体，其中R1选自卤素或C1-C3烷基；R2选自卤素或CN；R3选自卤素，或C1-C3卤代烷基；R4选自卤素；R5选自H或卤素；R6选自C1-C3烷基，C1-C3卤代烷基或C1-C5烷氧基烷基；R7选自C1-C5烷基；R8选自氢或C1-C5烷基。与先前技术中的化合物相比，一般式I的化合物在低浓度下具有更高的活性。特别是，本发明的化合物在低于1 ppm的浓度下仍具有60%或更高的杀虫活性。这大大减少了使用的化合物量和化合物在农田中的残留物，因此对环境友好。