2-(1',3'-Dioxan-2'-yl)ethyl amine | 118599-06-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-(1',3'-Dioxan-2'-yl)ethyl amine
• 英文别名: 2-(2-aminoethyl)-1,3-dioxane；2-(1,3-dioxan-2-yl)ethanamine
• CAS: 118599-06-7
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: GOATYYIBQPEBFY-UHFFFAOYSA-N

物化性质

• 沸点：
  201.8±15.0 °C(Predicted)
• 密度：
  1.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1',3'-Dioxan-2'-yl)ethyl amine 在 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 生成 [(4S,6S,7R,8S)-11-[2-(1,3-dioxan-2-yl)ethoxy]-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
  参考文献：
  名称：

  Preparation and antitumor activity of additional mitomycin A analogs

  摘要：

  On the basis of qualitative structure-activity relationships developed in the preceding article, a series of 32 new mitomycin A analogues were prepared and tested in antitumor screens. Seven of them gave greater prolongation of life (ILS) than mitomycin C in the mouse P388 leukemia assay. They included examples with 7-O substituents such as cyclic ethers and nitrogen heterocycles. A Hansch analysis was attempted with log P and MR as the independent variables, but no statistically significant correlation could be made. Seven compounds, chosen mainly for their good potency (MED), were tested in the subcutaneous B16 melanoma assay in mice and four of them showed greater ILS than mitomycin C.

  DOI：

  10.1021/jm00123a036
• 作为产物：
  描述：

  2-[2-(1,3-Dioxan-2-yl)ethyl]isoindole-1,3-dione 生成 2-(1',3'-Dioxan-2'-yl)ethyl amine
  参考文献：
  名称：

  SAMI, SALAH M.;REMERS, WILLIAM A.;BRADNER, WILLIAM T., J. MED. CHEM., 32,(1989) N, C. 703-708

  摘要：

  DOI：

文献信息

• OPTICAL RECORDING MEDIUM AND COMPOUND USED FOR THE SAME
  申请人：SHIOZAKI Hiroyoshi

  公开号：US20090306376A1

  公开（公告）日：2009-12-10

  A compound comprising a ring structure including a ring composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded to the ring structure.

  一种化合物，包括一个环结构，其中包括由四个碳原子和两个氮原子组成的环，以及与环结构相结合的取代或未取代的氨基团。
• [EN] BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS<br/>[FR] DÉRIVÉS DE BENZOFURANE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE BROMODOMAINE
  申请人：GLAXOSMITHKLINE IP NO 2 LTD

  公开号：WO2019068783A1

  公开（公告）日：2019-04-11

  The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及公式（I）的化合物及其盐，含有这种化合物的药物组合物以及它们在治疗中的应用。
• Cobalt(II) Chloride-Catalyzed Chemoselective Sodium Borohydride Reduction of Azides in Water
  作者：Francesco Fringuelli、Ferdinando Pizzo、Luigi Vaccaro

  DOI：10.1055/s-2000-6389

  日期：——

  Reduction of azides to amines and amides was carried out with NaBH4/CoCl2 · 6 H2O in sole water at 25 °C under catalytic heterogeneous conditions. A broad spectrum of azides was reduced in a short time, chemoselectively in high yield and purity.

  将叠氮化物还原为胺和酰胺是在催化非均相条件下使用 NaBH4/CoCl2·6 H2O 在 25 °C 的单一水中进行的。广谱叠氮化物在短时间内被还原，化学选择性高产率和纯度。
• 6-substituted mitomycin analogs
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0324109A2

  公开（公告）日：1989-07-19

  Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula V, wherein: Y is hydrogen or lower alkyl; and X is a radical of the formula -O-R, wherein R is: N,N-di(hydroxy lower alkyl)amino lower alkyl, or tri-lower alkoxy silyl lower alkyl, or cyclo lower alkyl, or halo substituted lower alkoxy lower alkyl, or tetrahydro pyranyl, or carboethoxy lower alkyl, or 1-lower alkyl pyrrolidinyl lower alkyl, or N-pyrrolidinyl lower alkyl, or 1-lower alkyl pyrrolydinyl, or dioxanyl, or hydroxy lower alkenyl, or hydroxy lower alkyl thio lower alkyl thio lower alkyl, or dioxanyl lower alkyl, or lower alkyl thio lower alkyl, or phenyl thio lower alkyl, or phenoxy lower alkyl, or thiophenyl lower alkyl, or 1-lower alkyl piperidyl, or alkyl carbonyl amino alkyl, or N-­piperidyl lower alkyl, or lower alkoxy lower alkyl or lower alkyl thio hydroxy lower alkyl, or 1-lower alkyl N-­piperazinyl lower alkyl, or N-thiomorpholinyl lower alkyl.

  治疗动物肿瘤性疾病状态的新方法，该方法包括施用治疗有效量的式 V 化合物、 其中Y 是氢或低级烷基；X 是式 -O-R 的基团，其中 R 是： N,N-二(羟基低级烷基)氨基低级烷基，或三低级烷氧基硅基低级烷基，或环低级烷基，或卤代低烷氧基低级烷基，或四氢吡喃基，或羧氧基低级烷基，或 1-吡咯烷基低级烷基，或 N-吡咯烷基低级烷基，或 1-吡咯烷基低级烷基，或二噁烷基，或羟基低级烯基，或羟基低级烷基硫代低级烷基硫代低级烷基、或二噁烷基低级烷基，或低级烷基硫代低级烷基，或苯基硫代低级烷基，或苯氧基低级烷基，或噻吩基低级烷基，或 1-低级哌啶基烷基，或烷基羰基氨基烷基，或 N-哌啶基低级烷基，或低级烷氧基低级烷基，或低级烷基硫代羟基低级烷基，或 1-低级哌嗪基低级烷基，或 N-硫代吗啉基低级烷基。
• OPTICAL RECORDING MEDIUM AND COMPOUND USED IN THE OPTICAL RECORDING MEDIUM
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1672626A1

  公开（公告）日：2006-06-21

  There are provided an optical recording medium which enables recording and playback with high quality using laser of 300 nm to 900 nm and a novel compound. An optical recording medium wherein the percentage change (|[a2 - a1]/a1| × 100) of the recording layer thickness (a2) at the recorded site of recording layer (A) after recorded with laser light compared with the recording layer thickness (a1) at unrecorded site of said recording layer (A) is less than 25% and the amount of change (|a2 - a1|) of the recording layer thickness (a2) at recorded site of said recording layer (A) after recorded with laser light compared with the recording layer thickness (a1) at unrecorded site of said recording layer (A) is controlled to be less than 15 nm. A compound comprising a six-membered ring structure composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded.

  本发明提供了一种光学记录介质，利用波长为 300 纳米至 900 纳米的激光和一种新型化合物可实现高质量的记录和重放。 一种光学记录介质，其中用激光记录后，记录层（A）的记录部位的记录层厚度（a2）与未记录部位的记录层厚度（a1）相比的变化百分比（|[a2-a1]/a1| ×100）小于 25%，且所述记录层（A）的记录部位的记录层厚度（a2）与未记录部位的记录层厚度（a1）相比的变化量（|a2-a1|）小于 25%。a1|）的变化量控制在 15 nm 以下。 一种由四个碳原子和两个氮原子以及一个取代或未取代的氨基键合而成的六元环结构的化合物。