2-(2-methoxyethoxy)ethyl ethyl carbonate | 214470-03-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 2-(2-methoxyethoxy)ethyl ethyl carbonate
• 英文别名: Ethyl 2-(2-methoxyethoxy)ethyl carbonate
• CAS: 214470-03-8
• 化学式: C₈H₁₆O₅
• 分子量: 192.212
• InChiKey: FXYVSFOJRIWVSV-UHFFFAOYSA-N

物化性质

• 沸点：
  85 °C(Press: 0.6 Torr)
• 密度：
  1.049±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  邻氨基苯甲酸 、 2-(2-methoxyethoxy)ethyl ethyl carbonate 在 NaY-faujasite 作用下， 反应 18.0h， 以87%的产率得到2-(乙胺)苯甲酸
  参考文献：
  名称：

  Synthesis of mono-N-substituted functionalized anilines

  摘要：

  本发明涉及一种利用来自有机碳酸酯类的烷基化剂，优选为二烷基、二苄基和二烯丙基类型，在与与硅铝酸盐类相关的适当催化剂存在的情况下，直接和选择性合成单-N-取代官能化苯胺的方法。

  公开号：

  US20040127747A1
• 作为产物：
  描述：

  二乙二醇单甲醚 、 碳酸二乙酯 生成 2-(2-methoxyethoxy)ethyl ethyl carbonate
  参考文献：
  名称：

  Reaction of Primary Aromatic Amines with Alkyl Carbonates over NaY Faujasite:  A Convenient and Selective Access to Mono-N-alkyl Anilines

  摘要：

  At atmospheric pressure and at 130-160 degreesC, primary aromatic amines (p-XC6H4NH2, X = H, Cl, NO2) are mono-N-alkylated in a single step, with symmetrical and asymmetrical dialkyl carbonates [ROCOOR', R = Me, R' = MeO(CH2)(2)O(CH2)(2); R = R' = Et; R = R' = benzyl; R = R' = allyl; R = Et, R' = MeO(CH2)(2)O(CH2)(2)], in the presence of a commercially available NaY faujasite. No solvents are required. Mono-N-alkyl anilines are obtained with a very high selectivity (90-97%), in good to excellent yields (68-94%), on a preparative scale. In the presence of triglyme as a solvent, the mono-N-alkyl selectivity is independent of concentration and polarity factors. The reaction probably takes place within the polar zeolite cavities, and through the combined effect of the dual acid-base properties of the catalyst.

  DOI：

  10.1021/jo0006728

文献信息

• SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG
  申请人：Shionogi & Co., Ltd.

  公开号：US20150111854A1

  公开（公告）日：2015-04-23

  The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.
• US8007938B2
  申请人：——

  公开号：US8007938B2

  公开（公告）日：2011-08-30
• US8987441B2
  申请人：——

  公开号：US8987441B2

  公开（公告）日：2015-03-24
• US9758515B2
  申请人：——

  公开号：US9758515B2

  公开（公告）日：2017-09-12
• Synthesis of mono-N-substituted functionalized anilines
  申请人：CONSORZIO INTERUNIVERSITARIO NAZIONALE "LA CHIMICA PER L'AMBIENTE"

  公开号：US20040127747A1

  公开（公告）日：2004-07-01

  The present invention relates to a process for direct and selective synthesis of mono-N-substituted functionalized anilines by using alkylating agents selected from the class of organic carbonates, preferably of the dialkyl, dibenzyl and diallyl types, in the presence of suitable catalysts that are chemically related to the class of aluminosilicates.

  本发明涉及一种利用来自有机碳酸酯类的烷基化剂，优选为二烷基、二苄基和二烯丙基类型，在与与硅铝酸盐类相关的适当催化剂存在的情况下，直接和选择性合成单-N-取代官能化苯胺的方法。