(+/-)-4-(4-methoxydibenzo[b,d]furan-1-yl)-2-azolanone | 874673-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (+/-)-4-(4-methoxydibenzo[b,d]furan-1-yl)-2-azolanone
• 英文别名: 4-(4-methoxydibenzofuran-1-yl)pyrrolidin-2-one
• CAS: 874673-10-6
• 化学式: C₁₇H₁₅NO₃
• 分子量: 281.311
• InChiKey: LESDYBXZOZEHDB-UHFFFAOYSA-N

物化性质

• 沸点：
  541.8±50.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+/-)-4-(4-methoxydibenzo[b,d]furan-1-yl)-2-azolanone 在 铜 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 (+/-)-1-(3,5-dimethylphenyl)-4-(4-methoxydibenzo[b,d]furan-1-yl)pyrrolidine-2-one
  参考文献：
  名称：

  [EN] NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  [FR] NOUVEAUX COMPOSES TRICYCLIQUES UTILISES DANS LE TRAITEMENT DE TROUBLES INFLAMMATOIRES ET ALLERGIQUES, PROCEDE DE PREPARATION ASSOCIE, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  公开号：

  WO2006011024A3
• 作为产物：
  描述：

  methyl 3-(4-methoxydibenzo[b,d]furan-1-yl)-4-nitrobutanoate 在 palladium 10% on activated carbon 氢气 作用下， 以 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 24.0h， 生成 (+/-)-4-(4-methoxydibenzo[b,d]furan-1-yl)-2-azolanone
  参考文献：
  名称：

  [EN] NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  [FR] NOUVEAUX COMPOSES TRICYCLIQUES UTILISES DANS LE TRAITEMENT DE TROUBLES INFLAMMATOIRES ET ALLERGIQUES, PROCEDE DE PREPARATION ASSOCIE, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  公开号：

  WO2006011024A3

文献信息

• [EN] New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process fortheir preparation and pharmaceutical compositions containing them
  申请人：GLENMARK PHARMACEUTICALS LTD

  公开号：WO2006011024A9

  公开（公告）日：2006-06-08

  [EN] The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention also relates to Phosphodiesterase type 4 (PDE4) inhibitor compounds which down regulate or inhibit the production of TNF-a and therefore are useful in the treatment of variety of allergic and inflammatory diseases including asthma and chronic obstructive pulmonary disease (COPD). The present invention also relates to a process for the preparation of the novel heterocyclic compounds.
  [FR] L'invention concerne de nouveaux composés hétérocycliques, leurs analogues, leurs tautomères, leurs régioisomères, leurs stéréoisomères, leurs énantiomères, leurs diastéréomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, leurs oxydes appropriés, leurs solvates pharmaceutiquement acceptables et des compositions contenant lesdits composés. L'invention concerne également des composés inhibiteurs de la phosphodiéstérase type 4 (PDE4) qui régulent par le bas ou inhibent la production de TNF-a et ils sont utilisés dans le traitement d'une pluralité de maladies allergiques ou pulmonaires notamment l'asthme et la bronchopneumopathie chronique obstructive (BPCO). L'invention concerne, en outre, un procédé de préparation des nouveaux composés hétérocycliques.
• [EN] TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS<br/>[FR] COMPOSÉS TRICYCLIQUES EN TANT QU'INHIBITEURS DE LA PHOSPHODIESTÉRASE-10
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2011132051A2

  公开（公告）日：2011-10-27

  The present invention provides Phosphodiesterase- 10 inhibitors. In particular, tricyclic derivatives described herein are useful as Phosphodiesterase- 10 inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Phosphodiesterase- 10. (Formula I) (I)
• [EN] NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES TRICYCLIQUES UTILISES DANS LE TRAITEMENT DE TROUBLES INFLAMMATOIRES ET ALLERGIQUES, PROCEDE DE PREPARATION ASSOCIE, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：GLENMARK PHARMACEUTICALS LTD

  公开号：WO2006011024A3

  公开（公告）日：2006-03-30