6-Aminobenzo[d]oxazole-2-carboxylic acid | 372953-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 6-Aminobenzo[d]oxazole-2-carboxylic acid
• 英文别名: 6-amino-1,3-benzoxazole-2-carboxylic acid
• CAS: 372953-12-3
• 化学式: C₈H₆N₂O₃
• 分子量: 178.14
• InChiKey: PHDNFSYZQTUVCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Cbi analogues of cc-1065 and the duocarmycins
  申请人：Boger L. Dale

  公开号：US20050014700A1

  公开（公告）日：2005-01-20

  132 CBI analogues of CC-1 065 and the duocarmycins having dimeric monocyclic, bicyclic, and tricyclic heteroaromatics substituents were synthesized by a parallel route. The resultant analogues were evaluated with respect to their catalytic and cytotoxic activities. The relative contribution of the various dimeric monocyclic, bicyclic, and tricyclic heteroaromatics substituents within the DNA binding domain were characterized. Several of the resultant CBI analogues of CC-1065 and the duocarmycins were characterized as having enhanced catalytic and cytotoxic activities and were identified as having utility as anti-cancer agents.

  通过平行路线合成了 132 种 CC-1 065 的 CBI 类似物以及具有二聚单环、双环和三环杂芳香族取代基的二羧基二氢胭脂虫酰胺。对所得到的类似物的催化和细胞毒性活性进行了评估。对 DNA 结合域中各种二元单环、双环和三环杂芳烃取代基的相对贡献进行了表征。结果表明，CC-1065 和双胭脂虫酰胺的几个 CBI 类似物具有更强的催化和细胞毒性活性，可用作抗癌药物。
• CBI ANALOGUES OF CC-1065 AND THE DUOCARMYCINS
  申请人：The Scripps Research Institute

  公开号：EP1423110A2

  公开（公告）日：2004-06-02
• EP1423110A4
  申请人：——

  公开号：EP1423110A4

  公开（公告）日：2005-04-27
• [EN] CBI ANALOGUES OF CC-1065 AND THE DUOCARMYCINS<br/>[FR] ANALOGUES CBI DE CC-1065 ET DES DUOCARMYCINES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2003022806A2

  公开（公告）日：2003-03-20

  132 CBI analogues of CC-1 065 and the duocarmycins having dimeric monocyclic, bicyclic, and tricyclic heteroaromatics substituents were synthesized by a parallel route. The resultant analogues were evaluated with respect to their catalytic and cytotoxic activities. The relative contribution of the various dimeric monocyclic, bicyclic, and tricyclic heteroaromatics substituents within the DNA binding domain were characterized. Several of the resultant CBI analogues of CC-1065 and the duocarmycins were characterized as having enhanced catalytic and cytotoxic activities and were identified as having utility as anti-cancer agents.