Naphthalen-1-yl-(4-phenylpiperazin-1-yl)methanone | 339235-61-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthalen-1-yl-(4-phenylpiperazin-1-yl)methanone
• CAS: 339235-61-9
• 化学式: C₂₁H₂₀N₂O
• 分子量: 316.403
• InChiKey: BKEQSWHWXKWGNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-苯基哌嗪 、 一氧化碳 、 1-碘萘 在 potassium phosphate 、 Pd((imidazolium)acetonaphthene)(allyl)Cl 作用下， 以 甲苯 为溶剂， 90.0 ℃ 、101.33 kPa 条件下， 反应 19.0h， 以80%的产率得到Naphthalen-1-yl-(4-phenylpiperazin-1-yl)methanone
  参考文献：
  名称：

  Highly Efficient Aminocarbonylation of Iodoarenes at Atmospheric Pressure Catalyzed by a Robust Acenaphthoimidazolyidene Allylic Palladium Complex

  摘要：

  A robust allylic palladium-NHC complex was developed and exhibited extremely high catalytic activity toward aminocarbonylation of various (hetero)aryl iodides under atmospheric carbon monoxide pressure, in which a broad range of secondary and primary amines were well tolerated. In addition, the concise synthesis of an anticancer drug tamibarotene was accomplished even in a gram scale, further highlighting the practical applicability of the protocol.

  DOI：

  10.1021/ol401550h

文献信息

• Highly Efficient Aminocarbonylation of Iodoarenes at Atmospheric Pressure Catalyzed by a Robust Acenaphthoimidazolyidene Allylic Palladium Complex
  作者：Weiwei Fang、Qinyue Deng、Mizhi Xu、Tao Tu

  DOI：10.1021/ol401550h

  日期：2013.7.19

  A robust allylic palladium-NHC complex was developed and exhibited extremely high catalytic activity toward aminocarbonylation of various (hetero)aryl iodides under atmospheric carbon monoxide pressure, in which a broad range of secondary and primary amines were well tolerated. In addition, the concise synthesis of an anticancer drug tamibarotene was accomplished even in a gram scale, further highlighting the practical applicability of the protocol.