methyl-(1-nitroso-[2]naphthyl)-amine | 32600-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl-(1-nitroso-[2]naphthyl)-amine
• 英文别名: Methyl-(1-nitroso-[2]naphthyl)-amin；1-Nitroso-2-methylamino-naphthalin；1-Nitroso-2-(N-methyl)-naphthylamin；2-Methylamino-1-nitrosonaphthalene；N-methyl-1-nitrosonaphthalen-2-amine
• CAS: 32600-54-7
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: BTBLSOIHBQDNKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl-(1-nitroso-[2]naphthyl)-amine 在 palladium on activated charcoal manganese(IV) oxide 、 氢气 作用下， 以 甲苯 、 苯 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 7.0h， 生成 3-Methyl-2-(pyridin-4-yl)-3H-naphtho[1,2-d]imidazole
  参考文献：
  名称：

  3-烷基-2-芳基-3H-萘并[1,2-d]咪唑类，一类新型的非酸性抗炎药。

  摘要：

  合成了新型的3-烷基-2-芳基-3H-萘[1,2-d]咪唑类，并在角叉菜胶诱发的爪水肿，棉丸诱发的肉芽肿和佐剂诱发的多关节炎试验中用作抗炎药。还测试了止痛，解热和胃溃疡的作用。讨论了构效关系。选择一种化合物3-（1-甲基乙基）-2-（4-甲氧基苯基）-3H-萘并[1,2-d]咪唑（35）作为非酸性抗炎和镇痛药进行临床试验。

  DOI：

  10.1021/jm00371a010
• 作为产物：
  描述：

  N-methyl-N-(naphthalen-2-yl)nitrous amide 在 盐酸 作用下， 生成 methyl-(1-nitroso-[2]naphthyl)-amine
  参考文献：
  名称：

  Morgan; Evens, Journal of the Chemical Society, 1919, vol. 115, p. 1141

  摘要：

  DOI：

文献信息

• Antiinflammatory 3H-naphtho[1,2-d]imidazoles
  申请人：Gruppo Lepetit S.p.A.

  公开号：US04435417A1

  公开（公告）日：1984-03-06

  3H-naphtho[1,2-d]imidazole derivatives of formula ##STR1## wherein R stands for (C.sub.1-6)alkyl, (C.sub.3-6)alkenyl, (C.sub.3-6)alkynyl or (C.sub.3-7)cycloalkyl, R.sub.1 and R.sub.2, each independently may represent hydrogen, halogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkylthio, (C.sub.1-4)alkoxy or halo(C.sub.1-4)alkoxy, R.sub.3 stands for hydrogen, hydroxy, methoxy, ethoxy, or mono- or di-methylamino, and R.sub.4 represents hydrogen or (C.sub.1-4)alkyl. Also described and claimed are their use as antiinflammatory agents and the pharmaceutical compositions containing them.

  化合物公式为##STR1## 其中R代表(C.sub.1-6)烷基，(C.sub.3-6)烯基，(C.sub.3-6)炔基或(C.sub.3-7)环烷基，R.sub.1和R.sub.2，各自独立地可以代表氢，卤素，(C.sub.1-4)烷基，(C.sub.1-4)烷基硫醚，(C.sub.1-4)烷氧基或卤代(C.sub.1-4)烷氧基，R.sub.3代表氢，羟基，甲氧基，乙氧基或单甲基或二甲基氨基，R.sub.4代表氢或(C.sub.1-4)烷基。还描述和声明它们作为抗炎药物的用途和含有它们的制药组合物。
• Antimicrobial 3H-naphtho[1,2-d]imidazoles
  申请人：Gruppo Lepetit S.p.A.

  公开号：US04340607A1

  公开（公告）日：1982-07-20

  3H-naphtho[1,2-d]imidazole derivatives of formula ##STR1## wherein R stands for (C.sub.1-6)alkyl, (C.sub.3-6)alkenyl, (C.sub.3-6)alkynyl or (C.sub.3-7)cycloalkyl, R.sub.1 and R.sub.2, each independently may represent hydrogen, halogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkylthio, (C.sub.1-4)alkoxy or halo(C.sub.1-4)alkoxy, R.sub.3 and R.sub.4, each independently, represent hydrogen or (C.sub.1-4)alkoxy, R.sub.5 stands for hydrogen, (C.sub.1-4)alkyl, (C.sub.3-4)alkoxy, mono- and di-(C.sub.2-4)alkylamino, (C.sub.2-4)alkanoylamino, carboxymethoxy and [carbo(C.sub.1-4)alkoxy]methoxy and R.sub.6 is hydrogen or R.sub.4 and R.sub.6 taken together may represent a methylenedioxy radical with the proviso that when R.sub.5 is hydrogen at least one of R.sub.3 and R.sub.4 must be different from hydrogen, useful as antimicrobial agents.

  公式为##STR1##的3H-萘并[1,2-d]咪唑衍生物，其中R代表（C.sub.1-6）烷基，（C.sub.3-6）烯基，（C.sub.3-6）炔基或（C.sub.3-7）环烷基，R.sub.1和R.sub.2可以独立地表示氢，卤素，（C.sub.1-4）烷基，（C.sub.1-4）烷基硫醚，（C.sub.1-4）烷氧基或卤代（C.sub.1-4）烷氧基，R.sub.3和R.sub.4可以独立地表示氢或（C.sub.1-4）烷氧基，R.sub.5代表氢，（C.sub.1-4）烷基，（C.sub.3-4）烷氧基，单烷基和双烷基（C.sub.2-4）氨基，（C.sub.2-4）烷酰胺基，羧甲氧基和[羧甲（C.sub.1-4）烷氧基]甲氧基，R.sub.6为氢或R.sub.4和R.sub.6共同表示亚甲二氧基基团，但当R.sub.5为氢时，R.sub.3和R.sub.4中至少有一个不能为氢，作为抗微生物剂有用。
• New 3H-naphtho(1,2-d)imidazoles, processes for preparing them, compounds for use as antiinflammatory and antimicrobial agents and compositions for that use containing them
  申请人：GRUPPO LEPETIT S.P.A.

  公开号：EP0012866A1

  公开（公告）日：1980-07-09

  3H-naphth[1,2,-d] imidazole derivates of formula wherein R stands for (C1-6)aslalkyl, (C3-6)alkenyl, (C3-6) alkynyl or (33-7)cycloalkyl. R1 and R2, each independently may represent hydrogen, halogen, (C1-4)alkyl, (C1-4)alkytthio. (C1-4)alkoxy or halo(C1-4)alkoxy and the symbol A represents a 5- or 6-membered hetaoeromatic ring or a phenyl radical optionally substituted, are claimed. Also described and claimed are processes for preparing the novel compounda, their use as antiinflammatory and antimicrobial agents and pharmaceutical compositions con- taming them.

  式中 R 代表 (C1-6)烷基、(C3-6)烯基、(C3-6)炔基或 (33-7)cycloalkyl 的 3H-naphth[1,2,-d] imidazole 衍生物。 R1 和 R2 可各自独立地代表氢、卤素、(C1-4)烷基、(C1-4)烷硫基、(C1-4)烷氧基或(C1-4)环烷基。 (还描述和要求了制备新型化合物a 的工艺、它们作为抗炎剂和抗菌剂的用途以及含有它们的药物组合物。
• Fischer,O.; Dietrich; Weiss, Journal fur praktische Chemie (Leipzig 1954), 1920, vol. <2> 100, p. 170 Anm.
  作者：Fischer,O.、Dietrich、Weiss

  DOI：——

  日期：——
• Fischer,O.; Dietrich; Weiss, Journal fur praktische Chemie (Leipzig 1954), 1920, vol. <2> 100, p. 168
  作者：Fischer,O.、Dietrich、Weiss

  DOI：——

  日期：——