2-[(E)-2-(4-乙酰氨基-2-磺基苯基)乙烯基]-5-(2,5-二氧代吡咯-1-基)苯磺酸 | 118121-38-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2-[(E)-2-(4-乙酰氨基-2-磺基苯基)乙烯基]-5-(2,5-二氧代吡咯-1-基)苯磺酸
• 英文名称: 5-acetamido-2-[(E)-2-[4-(2,5-dioxopyrrol-1-yl)-2-sulfophenyl]ethenyl]benzenesulfonic acid
• CAS: 118121-38-3
• 化学式: C₂₀H₁₆N₂O₉S₂
• 分子量: 492.5
• InChiKey: VVMKDNFTYDHDJS-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  192
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid
  申请人：Encore Health, LLC

  公开号：US20150246903A9

  公开（公告）日：2015-09-03

  Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

  公开了二硫化合物及其衍生物。这些药物对治疗眼部疾病，特别是老视和白内障，具有益处。
• [EN] ANTIMICROBIAL AGENTS AND SCREENING METHODS<br/>[FR] AGENTS ANTIMICROBIENS ET PROCÉDÉS DE CRIBLAGE
  申请人：HARVARD COLLEGE

  公开号：WO2015143164A1

  公开（公告）日：2015-09-24

  Disclosed herein are antibacterial and antimicrobial compositions and methods of use. Also disclosed are screening assays for identification of an agent that specifically inhibits DsbB or bVKOR. Such methods are useful, for example, in identifying antibacterial and antimicrobial agents and compositions.

  本公开涉及抗菌和抗微生物组合物及其使用方法。还公开了用于识别特异抑制DsbB或bVKOR的试剂的筛选分析方法。这些方法例如在鉴定抗菌和抗微生物试剂和组合物方面是有用的。
• Choline Esters
  申请人：Garner William

  公开号：US20100317725A1

  公开（公告）日：2010-12-16

  Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

  提供了含有还原剂胆碱酯的化合物、配方和方法，特别是丙硫氨酸或其衍生物。这些化合物可以通过局部眼部途径给予，以治疗或预防氧化损伤。
• MERCAPTAN AND SELENO-MERCAPTAN COMPOUNDS AND METHODS OF USING THEM
  申请人：Garner William

  公开号：US20090124683A1

  公开（公告）日：2009-05-14

  Novel mercaptan compounds, particularly those including a photolabile protecting group, are described as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

  本发明描述了一种新型的巯基化合物，尤其是包括光敏保护基团的巯基化合物，以及使用这些化合物预防和治疗眼部损伤和疾病的方法。
• Dithiol Compounds, Derivatives, and Uses Therefor
  申请人：Encore Health, LLC

  公开号：US20140243385A1

  公开（公告）日：2014-08-28

  Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract. Also disclosed are novel mercaptan compounds, particularly those including a photolabile protecting group, as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

  本发明揭示了二硫化合物及其衍生物。这些药剂可用于治疗眼部疾病，特别是老视和白内障。本发明还揭示了新型巯基化合物，特别是那些包括光敏保护基的化合物，以及使用这些化合物预防和治疗眼部损伤和疾病的方法。