2-Dimethylamino-4,6-dioxo-3,4,5,6-tetrahydropteridin | 103438-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2-Dimethylamino-4,6-dioxo-3,4,5,6-tetrahydropteridin
• 英文别名: 2-(Dimethylamino)-3,5-dihydropteridine-4,6-dione；2-(dimethylamino)-3,5-dihydropteridine-4,6-dione
• CAS: 103438-10-4
• 化学式: C₈H₉N₅O₂
• 分子量: 207.192
• InChiKey: UKEPZMKMWITKSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-ethoxy-2-dimethylamino-4(3H)-oxopteridine 在 盐酸 作用下， 反应 0.75h， 以23%的产率得到2-Dimethylamino-4,6-dioxo-3,4,5,6-tetrahydropteridin
  参考文献：
  名称：

  Pteridines, CIV. Regioselective Alkoxylation of Pteridines at the 6-Position by N-Bromo-succinimide and Alcohol

  摘要：

  Reaction of 1,3-dimethyllumazine with N-bromosuccinimide or bromine in an appropriate alcohol afforded 6-alkoxy-1,3-dimethyllumazine. N-Iodosuccinimide or iodine also brought about the same reaction. This procedure was applicable to other pteridine compounds, such as 2-dimethylamino-4(3H)-oxopteridine. The mechanism of this alkoxylation reaction is discussed.

  DOI：

  10.3987/com-94-6997

文献信息

• Boehme, Manfred; Hutzenlaub, Wolfgang; Richter, Wilhelm J., Liebigs Annalen der Chemie, 1986, # 10, p. 1705 - 1717
  作者：Boehme, Manfred、Hutzenlaub, Wolfgang、Richter, Wilhelm J.、Elstner, Erich F.、Huttner, Gottfried、et al.

  DOI：——

  日期：——
• Pteridines, CIV. Regioselective Alkoxylation of Pteridines at the 6-Position by N-Bromo-succinimide and Alcohol
  作者：Takashi Sugimoto、Wolfgang Pfleiderer

  DOI：10.3987/com-94-6997

  日期：——

  Reaction of 1,3-dimethyllumazine with N-bromosuccinimide or bromine in an appropriate alcohol afforded 6-alkoxy-1,3-dimethyllumazine. N-Iodosuccinimide or iodine also brought about the same reaction. This procedure was applicable to other pteridine compounds, such as 2-dimethylamino-4(3H)-oxopteridine. The mechanism of this alkoxylation reaction is discussed.