ethyl (2-morpholin-4-yl-1,3-thiazol-4-yl)acetate | 329906-01-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: ethyl (2-morpholin-4-yl-1,3-thiazol-4-yl)acetate
• 英文别名: Ethyl 2-(2-morpholinothiazol-4-yl)acetate；ethyl 2-(2-morpholin-4-yl-1,3-thiazol-4-yl)acetate
• CAS: 329906-01-6
• 化学式: C₁₁H₁₆N₂O₃S
• mdl: MFCD02710102
• 分子量: 256.326
• InChiKey: NDZOLYPESIETMS-UHFFFAOYSA-N

物化性质

• 沸点：
  387.4±52.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.636
• 拓扑面积：
  79.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl (2-morpholin-4-yl-1,3-thiazol-4-yl)acetate 在 sodium hydroxide 、 三乙胺 作用下， 以 吡啶 、 乙醇 为溶剂， 反应 20.0h， 生成 [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid
  参考文献：
  名称：

  Palladium-catalyzed Suzuki cross-coupling of aryl halides with aryl boronic acids in the presence of glucosamine-based phosphines

  摘要：

  Carbohydrate-substituted phosphines are easily obtained in quite good yields by coupling of protected or non-protected D-glucosamine with the corresponding diphenylphosphino acid. These neutral ligands, in association with palladium acetate, are very active catalysts in the Suzuki cross-coupling reaction. The polyhydroxy phosphines are more active than the peracetylated phosphines. The process tolerates electron-rich as well as electron-poor substituents. Excellent turnovers, up to 97 000 are observed. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(03)00636-3
• 作为产物：
  描述：

  4-吗啉硫代甲酰胺 、 4-氯乙酰乙酸乙酯 在 水 、 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以100%的产率得到ethyl (2-morpholin-4-yl-1,3-thiazol-4-yl)acetate
  参考文献：
  名称：

  WO2008/73936

  摘要：

  公开号：

文献信息

• WO2008/73934
  申请人：——

  公开号：——

  公开（公告）日：——
• WO2008/73936
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS<br/>[FR] DERIVES DE CARBOXAMIDE UTILISES EN TANT QUE MODULATEURS DES CANAUX IONIQUES
  申请人：WYETH CORP

  公开号：WO2008073936A1

  公开（公告）日：2008-06-19

  [EN] The present teachings provide compounds of Formula (I) wherein Ar, R¹, R², R³, X, p and n are defined herein. The present teachings also provide processes for producing said compounds and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
  [FR] L'invention concerne des composés de Formule (I) dans laquelle Ar, R¹, R², R³, X, p et n sont tels que définis dans la description. L'invention concerne également des procédés de production de ces composés ainsi que des méthodes de traitement d'une affection ou d'un trouble pathologique, ou d'atténuation d'un symptôme associé, au moyen desdits composés. Les composés selon l'invention peuvent être utiles dans la modulation de l'activité des canaux ioniques, notamment dans le traitement de diverses affections associées à la modulation anormale d'au moins un canal calcique sensible au voltage.
• WO2008/73461
  申请人：——

  公开号：——

  公开（公告）日：——
• Palladium-catalyzed Suzuki cross-coupling of aryl halides with aryl boronic acids in the presence of glucosamine-based phosphines
  作者：Robert Kolodziuk、Alexandra Penciu、Mustapha Tollabi、Eric Framery、Catherine Goux-Henry、Alexander Iourtchenko、Denis Sinou

  DOI：10.1016/s0022-328x(03)00636-3

  日期：2003.12

  Carbohydrate-substituted phosphines are easily obtained in quite good yields by coupling of protected or non-protected D-glucosamine with the corresponding diphenylphosphino acid. These neutral ligands, in association with palladium acetate, are very active catalysts in the Suzuki cross-coupling reaction. The polyhydroxy phosphines are more active than the peracetylated phosphines. The process tolerates electron-rich as well as electron-poor substituents. Excellent turnovers, up to 97 000 are observed. (C) 2003 Elsevier Science B.V. All rights reserved.