3-allyl-1H-indazole | 1441097-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 3-allyl-1H-indazole
• 英文别名: 3-Allylindazole；3-prop-2-enyl-2H-indazole
• CAS: 1441097-72-8
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.203
• InChiKey: QFPDGNBGRDHNDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯甲亚胺酸乙酯 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 copper diacetate 作用下， 以 乙醚 、 1,2-二氯乙烷 、 甲苯 为溶剂， 110.0~120.0 ℃ 、101.33 kPa 条件下， 反应 32.0h， 生成 3-allyl-1H-indazole
  参考文献：
  名称：

  Rh^III/Cu^II-Cocatalyzed Synthesis of 1H-Indazoles through C–H Amidation and N–N Bond Formation

  摘要：

  Substituted 1H-indazoles can be formed from readily available arylimidates and organo azides by Rh-III-catalyzed C-H activation/C-N bond formation and Cu-catalyzed N-N bond formation. For the first time the N-H-imidates are demonstrated to be good directing groups in C-H activation, also capable of undergoing intramolecular N-N bond formation. The process is scalable and green, with O-2 as the terminal oxidant and N-2 and H2O formed as byproducts. Moreover, the products could be transformed to diverse important derivatives.

  DOI：

  10.1021/ja4033555

文献信息

• Pyranoindazoles and their use for the treatment of glaucoma
  申请人：——

  公开号：US20030171418A1

  公开（公告）日：2003-09-11

  Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

  吡啶并吡唑类化合物已被披露。还公开了降低和控制正常或升高眼内压力的方法，以及使用含有本发明化合物之一或多个的组合物治疗青光眼的方法。
• INDAZOLE DERIVATIVES AND USES THEREOF
  申请人：Whitehead Institute for Bio-Medical Research

  公开号：US20150353503A1

  公开（公告）日：2015-12-10

  The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be a Candida species, Aspergillus species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds.

  本发明提供了新型化合物（例如，公式（I）化合物），以及其药学上可接受的盐、溶剂合物、水合物、多晶形、共晶体、互变异构体、立体异构体、同位素标记衍生物、前药和组合物。还提供了包含本发明化合物或其组合物的方法和试剂盒，用于治疗和/或预防真菌或原虫感染、抑制真菌或原虫酶的活性、杀灭真菌或原虫或抑制真菌或原虫的生长。真菌可能是念珠菌属、曲霉属或其他致病真菌种类。本发明化合物可以抑制真菌或原虫细胞色素b和/或真菌或原虫Hsp90的活性。本发明还提供了本发明化合物的合成方法。
• RUBBER-REINFORCING FIBER, RUBBER-FIBER COMPOSITE, AND PNEUMATIC TIRE USING SAME
  申请人：Bridgestone Corporation

  公开号：EP3363936A1

  公开（公告）日：2018-08-22

  Provided are: a rubber-reinforcing fiber, in which adhesion between a rubber and a fiber is enhanced and which is thereby capable of further improving the durability than before when used as a reinforcing material; a rubber-fiber composite; and a pneumatic tire using the same. The rubber-reinforcing fiber includes a core-sheath type composite fiber whose core portion is composed of a high-melting-point resin (A) having a melting point of 150°C or higher and sheath portion is composed of a resin material (B) having a melting point lower than that of the high-melting point resin (A). The resin material (B) contains an olefin-based polymer (X) and a vulcanization accelerator (F).

  本文提供了一种橡胶补强纤维，该纤维增强了橡胶和纤维之间的粘附力，因此在用作补强材料时，其耐用性比以前有了进一步提高；一种橡胶纤维复合材料；以及一种使用该纤维的充气轮胎。橡胶增强纤维包括芯鞘型复合纤维，其芯部由熔点为 150°C 或更高的高熔点树脂 (A) 组成，鞘部由熔点低于高熔点树脂 (A) 的树脂材料 (B) 组成。树脂材料（B）含有烯烃基聚合物（X）和硫化促进剂（F）。
• EP1392292A4
  申请人：——

  公开号：EP1392292A4

  公开（公告）日：2004-08-11
• PYRANOINDAZOLES AND THEIR USE FOR THE TREATMENT OF GLAUCOMA
  申请人：Alcon, Inc.

  公开号：EP1392292A2

  公开（公告）日：2004-03-03