2-<2-(3-pyridyl-E-ethenyl)>benzothiazole | 108850-37-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-<2-(3-pyridyl-E-ethenyl)>benzothiazole
• 英文别名: 2-(trans-2-[3]pyridyl-vinyl)-benzothiazole；2-(trans-2-[3]Pyridyl-vinyl)-benzothiazol；2-[(E)-2-pyridin-3-ylethenyl]-1,3-benzothiazole
• CAS: 108850-37-9
• 化学式: C₁₄H₁₀N₂S
• 分子量: 238.313
• InChiKey: RPTFDQQPDYHMFR-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯甲基-1,3-苯并噻唑 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-<2-(3-pyridyl-E-ethenyl)>benzothiazole
  参考文献：
  名称：

  Synthesis of Ethenylbenzothiazole Derivatives

  摘要：

  Ethenylbenzothiazoles were synthesized by the Horner-Emmons reaction of benzothiazolylmethylphosphonate with aldehydes under phase transfer catalytic conditions in 60-71% yields. Not only aromatic but also aliphatic aldehydes gave the desired products under these mild conditions in 66-71% yields.

  DOI：

  10.1080/00397919508013865

文献信息

• FUNCTIONALIZED LIPOSOMES FOR IMAGING MISFOLDED PROTEINS
  申请人：ALZECA BIOSCIENCES, LLC

  公开号：US20200261605A1

  公开（公告）日：2020-08-20

  Phospholipid-polymer-aromatic conjugates comprising binding ligands, liposome compositions including the phospholipid-polymer-aromatic conjugates, and binding ligands having an affinity for misfolded proteins are described. The phospholipid-polymer-aromatic conjugate may be represented by Structural Formula I: PL-AL-HP-X-BL (I). In Formula I, PL is a phospholipid, AL is an aliphatic linkage, HP is hydrophilic polymer, X is a link between the phospholipid-polymer and the binding ligand, and BL is polycyclic aromatic compound that functions as a binding ligand. The liposomal compositions may be useful for the imaging of misfolded and/or aggregated proteins.
• Synthesis of Ethenylbenzothiazole Derivatives
  作者：Setsuya Ohba、Takatoshi Kosaka、Toshio Wakabayashi

  DOI：10.1080/00397919508013865

  日期：1995.11

  Ethenylbenzothiazoles were synthesized by the Horner-Emmons reaction of benzothiazolylmethylphosphonate with aldehydes under phase transfer catalytic conditions in 60-71% yields. Not only aromatic but also aliphatic aldehydes gave the desired products under these mild conditions in 66-71% yields.