N-(2-Aminoethyl)-N'-(5-bromoquinoxalin-6-yl)thiourea | 134892-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(2-Aminoethyl)-N'-(5-bromoquinoxalin-6-yl)thiourea
• 英文别名: 1-(2-aminoethyl)-3-(5-bromoquinoxalin-6-yl)thiourea
• CAS: 134892-47-0
• 化学式: C₁₁H₁₂BrN₅S
• 分子量: 326.22
• InChiKey: PKKDYWFVHATGII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Methods of preventing and reducing the severity of stress-associated conditions
  申请人：——

  公开号：US20040266776A1

  公开（公告）日：2004-12-30

  The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatogical conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

  本发明提供了一种通过向受试者系统性给予有效量的布里莫尼定或其药用可接受的盐、酯、酰胺、立体异构体或混合物来预防或减轻受试者的压力相关症状严重程度的方法。根据本发明的方法可以治疗的压力相关症状包括但不限于消化不良、非心肌缺血相关的心动过速、惊恐发作、非炎症皮肤病、肌肉收缩障碍、与偏头痛相关的感觉过敏以及行为障碍。
• METHODS OF PREVENTING AND REDUCING THE SEVERITY OF STRESS-ASSOCIATED CONDITIONS
  申请人：Gil Daniel W.

  公开号：US20080207628A1

  公开（公告）日：2008-08-28

  The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatological conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

  本发明提供了一种通过系统给予受试者足够的布里莫啉或其药学上可接受的盐、酯、酰胺、立体异构体或混合物来预防或减轻应激相关疾病的方法。可以根据本发明的方法治疗的应激相关疾病包括但不限于消化不良、除心肌缺血相关的心动过速外的其他心动过速、惊恐发作、非炎症性皮肤病、肌肉收缩障碍、与偏头痛相关的感觉过敏和行为障碍。
• Methods of Preventing and Reducing the Severity of Stress-Associated Conditions
  申请人：Gil Daniel W.

  公开号：US20120302574A1

  公开（公告）日：2012-11-29

  The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatogical conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

  本发明提供了一种方法，通过向受试者系统性地给予有效量的布里莫啶或其药学上可接受的盐、酯、酰胺、立体异构体或混合物来预防或减轻受试者的应激相关疾病的严重程度。根据本发明的方法可以治疗的应激相关疾病包括但不限于消化不良、除心肌缺血相关心动过速外的其他心动过速、惊恐发作、非炎症性皮肤病、肌肉收缩障碍、与偏头痛相关的感觉过敏和行为障碍。
• TOPICAL DERMAL BRIMONIDINE COMPOSITIONS
  申请人：Allergan, Inc.

  公开号：US20130102612A1

  公开（公告）日：2013-04-25

  The present invention provides topical dermal compositions comprising an effective amount of brimonidine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier selected from the group consisting of drops, creams, gels and ointments, wherein the composition is suitable for application to skin.

  本发明提供一种局部皮肤组成物，其包括有效量的布里莫啶或其药学上可接受的盐，以及从滴剂、乳霜、凝胶和软膏中选择的药学上可接受的载体，其中该组成物适合用于皮肤上的应用。
• METHOD OF REDUCING THE SEVERITY OF INFLAMMATORY DERMATOLOGICAL CONDITIONS
  申请人：Allergan, Inc.

  公开号：US20130217694A1

  公开（公告）日：2013-08-22

  The present invention provides a method of reducing the severity of one or more symptoms of an inflammatory dermatological condition in a subject, comprising topically administering to the skin of a subject in need of such reduction an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof.

  本发明提供了一种减轻受试者炎症性皮肤病症状严重程度的方法，包括局部给予布里莫啉或其药学上可接受的盐、酯、酰胺、立体异构体或混合物，以有效剂量涂抹于需要减轻的受试者皮肤上。