3',6'-Bis(diethylamino)-2-(pyridin-2-ylamino)spiro[isoindole-3,9'-xanthene]-1-one | 1343487-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3',6'-Bis(diethylamino)-2-(pyridin-2-ylamino)spiro[isoindole-3,9'-xanthene]-1-one
• 英文别名: 3',6'-bis(diethylamino)-2-(pyridin-2-ylamino)spiro[isoindole-3,9'-xanthene]-1-one
• CAS: 1343487-70-6
• 化学式: C₃₃H₃₅N₅O₂
• 分子量: 533.673
• InChiKey: WVWQLTFZXJVMSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  罗丹明B 在 三乙胺 、 三氯氧磷 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 8.0h， 生成 3',6'-Bis(diethylamino)-2-(pyridin-2-ylamino)spiro[isoindole-3,9'-xanthene]-1-one
  参考文献：
  名称：

  Rhodamine-based derivatives for Cu2+ sensing: Spectroscopic studies, structure-recognition relationships and its test strips

  摘要：

  A rhodamine spirolactam/2-hydrazinopyridine derivative was synthesized and characterized, which exhibited high selectivity to Cu2+ over other metal cations. The Cu2+ recognition of this rhodamine derivative could be detected by fluorescence spectra, absorption spectra and an obvious color change which was observed easily by naked-eyes. The binding of this rhodamine derivative to Cu2+ is instantaneous and sensitive. Moreover, a linear relationship was found between the fluorescence intensity at 575 nm from 0.5 x 10(-6) M to 3.0 x 10(-6) M of Cu2+ concentration, and the limit of detection (LOD) was at low concentration of 2.11 x 10(-8) M, this would benefit for the establishment of standard working curves in practical Cu2+ detection. Additionally, we synthesized rhodamine spirolactam/2-aminomethylpyridine derivative and rhodamine spirolactam/phenylhydrazine derivative as analogs for elucidate the structure-recognition relationships. Finally, we prepared the test strips of rhodamine spirolactam/2-hydrazinopyridine derivative for practical chromogenic the Cu2+ detection. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.05.016

文献信息

• Rhodamine-based derivatives for Cu2+ sensing: Spectroscopic studies, structure-recognition relationships and its test strips
  作者：Yunxu Yang、Weiling Gao、Ruilong Sheng、Weili Wang、Hui Liu、Wumin Yang、Tianyi Zhang、Xuetao Zhang

  DOI：10.1016/j.saa.2011.05.016

  日期：2011.10

  A rhodamine spirolactam/2-hydrazinopyridine derivative was synthesized and characterized, which exhibited high selectivity to Cu2+ over other metal cations. The Cu2+ recognition of this rhodamine derivative could be detected by fluorescence spectra, absorption spectra and an obvious color change which was observed easily by naked-eyes. The binding of this rhodamine derivative to Cu2+ is instantaneous and sensitive. Moreover, a linear relationship was found between the fluorescence intensity at 575 nm from 0.5 x 10(-6) M to 3.0 x 10(-6) M of Cu2+ concentration, and the limit of detection (LOD) was at low concentration of 2.11 x 10(-8) M, this would benefit for the establishment of standard working curves in practical Cu2+ detection. Additionally, we synthesized rhodamine spirolactam/2-aminomethylpyridine derivative and rhodamine spirolactam/phenylhydrazine derivative as analogs for elucidate the structure-recognition relationships. Finally, we prepared the test strips of rhodamine spirolactam/2-hydrazinopyridine derivative for practical chromogenic the Cu2+ detection. (C) 2011 Elsevier B.V. All rights reserved.