5-(2-benzofuryl)-3-(cyanomethyl)-1H-pyrazole | 134161-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 5-(2-benzofuryl)-3-(cyanomethyl)-1H-pyrazole
• 英文别名: [3-(1-Benzofuran-2-yl)-1H-pyrazol-5-yl]acetonitrile；2-[3-(1-benzofuran-2-yl)-1H-pyrazol-5-yl]acetonitrile
• CAS: 134161-77-6
• 化学式: C₁₃H₉N₃O
• 分子量: 223.234
• InChiKey: QTXLTLVWXKWTKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  65.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(2-benzofuryl)-3-(cyanomethyl)-1H-pyrazole 在 sodium azide 、 氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以43%的产率得到5-(5-Benzofuran-2-yl-1H-pyrazol-3-ylmethyl)-1H-tetrazole
  参考文献：
  名称：

  Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles

  摘要：

  A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.060
• 作为产物：
  描述：

  6-(2-benzofuryl)-3-cyano-4-methylthio-2H-pyran-2-one 在 吡啶 、 一水合肼 作用下， 反应 4.0h， 以60%的产率得到5-(2-benzofuryl)-3-(cyanomethyl)-1H-pyrazole
  参考文献：
  名称：

  Ram, Vishnu Ji; Verma, Monika; Hussaini, Falak Anwer, Liebigs Annalen der Chemie, 1991, # 11, p. 1229 - 1231

  摘要：

  DOI：

文献信息

• RAM, VISHNU J.;VERMA, MONIKA;HUSSAINI, FALAK A.;SHOEB, A., J. CHEM. RES. (S),(1991) N, C. 98-99
  作者：RAM, VISHNU J.、VERMA, MONIKA、HUSSAINI, FALAK A.、SHOEB, A.

  DOI：——

  日期：——
• Ram, Vishnu Ji; Verma, Monika; Hussaini, Falak Anwer, Liebigs Annalen der Chemie, 1991, # 11, p. 1229 - 1231
  作者：Ram, Vishnu Ji、Verma, Monika、Hussaini, Falak Anwer、Shoeb, Aboo

  DOI：——

  日期：——
• Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles
  作者：Ashoke Sharon、Ramendra Pratap、Priti Tiwari、Arvind Srivastava、P.R. Maulik、Vishnu Ji Ram

  DOI：10.1016/j.bmcl.2005.02.060

  日期：2005.4

  A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity. (c) 2005 Elsevier Ltd. All rights reserved.