1-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-ethane-1,2-dione | 33420-84-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-ethane-1,2-dione
• 英文别名: 1-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)ethane-1,2-dione
• CAS: 33420-84-7
• 化学式: C₁₆H₁₄O₅S
• 分子量: 318.35
• InChiKey: IBDUKFHYEKMGLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  85.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-ethane-1,2-dione 在 palladium on activated charcoal 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 2-(4-Methanesulfonyl-phenyl)-3-(4-methoxy-phenyl)-pyrazine
  参考文献：
  名称：

  Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors

  摘要：

  Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO2NH2)/methylsulfonyl (SO2Me)-phenyl pharmaco-phores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. Smaller groups such as methoxy, methyl and fluoro when substituted at/around position-4 of the adjacent phenyl ring, have great impact on the selective COX-2 inhibitory activity of the series. Many potential compounds were obtained from a brief structure-activity relationship (SAR) study. Two of these, compounds 11 and 25 exhibited excellent in vivo activity in the established animal model of inflammation. Since compound 25 possessed an amenable sulfonamide group, two of its prodrugs 48 and 49 were also synthesized. Both of them have excellent in vivo potential, and represent a new class of COX-2 inhibitor. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.01.033
• 作为产物：
  描述：

  2-(4-甲氧基-苯基)-1-(4-甲基硫烷基-苯基)乙酮 在 selenium(IV) oxide 、 双氧水 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 5.0h， 生成 1-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-ethane-1,2-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors

  摘要：

  Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO2NH2)/methylsulfonyl (SO2Me)-phenyl pharmaco-phores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. Smaller groups such as methoxy, methyl and fluoro when substituted at/around position-4 of the adjacent phenyl ring, have great impact on the selective COX-2 inhibitory activity of the series. Many potential compounds were obtained from a brief structure-activity relationship (SAR) study. Two of these, compounds 11 and 25 exhibited excellent in vivo activity in the established animal model of inflammation. Since compound 25 possessed an amenable sulfonamide group, two of its prodrugs 48 and 49 were also synthesized. Both of them have excellent in vivo potential, and represent a new class of COX-2 inhibitor. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.01.033

文献信息

• Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors
  作者：Thomas E. Barta、Michael A. Stealey、Paul W. Collins、Richard M. Weier

  DOI：10.1016/s0960-894x(98)00627-1

  日期：1998.12

  The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.

  描述了一系列4,5-二芳基咪唑类似物的合成和活性。一种类似物的IC50为80 nM，对COX-1具有6750选择性，并在小鼠气袋模型中显示出体内效力。
• Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors
  作者：Sunil K. Singh、V. Saibaba、V. Ravikumar、Santosh V. Rudrawar、Pankaj Daga、C.Seshagiri Rao、V. Akhila、P. Hegde、Y.Koteswar Rao

  DOI：10.1016/j.bmc.2004.01.033

  日期：2004.4

  Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO2NH2)/methylsulfonyl (SO2Me)-phenyl pharmaco-phores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. Smaller groups such as methoxy, methyl and fluoro when substituted at/around position-4 of the adjacent phenyl ring, have great impact on the selective COX-2 inhibitory activity of the series. Many potential compounds were obtained from a brief structure-activity relationship (SAR) study. Two of these, compounds 11 and 25 exhibited excellent in vivo activity in the established animal model of inflammation. Since compound 25 possessed an amenable sulfonamide group, two of its prodrugs 48 and 49 were also synthesized. Both of them have excellent in vivo potential, and represent a new class of COX-2 inhibitor. (C) 2004 Elsevier Ltd. All rights reserved.