methyl acenaphtho[1,2-b]quinoxaline-9-carboxylate | 1364782-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: methyl acenaphtho[1,2-b]quinoxaline-9-carboxylate
• 英文别名: Methyl acenaphthyleno[1,2-b]quinoxaline-9-carboxylate
• CAS: 1364782-81-9
• 化学式: C₂₀H₁₂N₂O₂
• 分子量: 312.327
• InChiKey: LKENINMBDPUJBA-UHFFFAOYSA-N

物化性质

• 沸点：
  543.6±30.0 °C(Predicted)
• 密度：
  1.416±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-二氨基苯甲酸甲酯 、 苊醌 在 cerium(III) chloride heptahydrate 作用下， 以 甘油 为溶剂， 反应 5.0h， 以85%的产率得到methyl acenaphtho[1,2-b]quinoxaline-9-carboxylate
  参考文献：
  名称：

  Glycerin and CeCl₃ · 7H₂O: A New and Efficient Recyclable Reaction Medium for the Synthesis of Quinoxalines

  摘要：

  An efficient and environmentally benign process for the synthesis of quinoxalines has been developed using glycerine-cerium chloride as a reaction medium. This method is applicable to a variety of diketones and 1,2-phenylenediamines to afford the corresponding quinoxaline derivatives in excellent yields. The reaction medium was recovered and reused for further reactions without any problem.

  DOI：

  10.1080/00397911.2010.533050

文献信息

• Glycerin and CeCl₃ · 7H₂O: A New and Efficient Recyclable Reaction Medium for the Synthesis of Quinoxalines
  作者：A. Venkat Narsaiah、J. Kranthi Kumar

  DOI：10.1080/00397911.2010.533050

  日期：2012.3.15

  An efficient and environmentally benign process for the synthesis of quinoxalines has been developed using glycerine-cerium chloride as a reaction medium. This method is applicable to a variety of diketones and 1,2-phenylenediamines to afford the corresponding quinoxaline derivatives in excellent yields. The reaction medium was recovered and reused for further reactions without any problem.