6-chloro-N2-isopropyl-N2-methylpyrimidine-2,4-diamine | 1310481-10-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-chloro-N2-isopropyl-N2-methylpyrimidine-2,4-diamine
• 英文别名: 6-chloro-2-N-methyl-2-N-propan-2-ylpyrimidine-2,4-diamine
• CAS: 1310481-10-7
• 化学式: C₈H₁₃ClN₄
• 分子量: 200.671
• InChiKey: LCOJRVDUHHFOTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-chloro-N2-isopropyl-N2-methylpyrimidine-2,4-diamine 、 (3R)-(+)-3-(甲氨基)吡咯烷 以 异丙醇 为溶剂， 反应 1.0h， 生成 (R)-N2-isopropyl-N2-methyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine
  参考文献：
  名称：

  Triamino pyrimidines and pyridines as histamine H4 receptor modulators

  摘要：

  Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H-4 receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.017
• 作为产物：
  描述：

  4-氨基-2,6-二氯嘧啶 、 N-异丙基甲胺 在 N,N-二异丙基乙胺 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 以66%的产率得到6-chloro-N2-isopropyl-N2-methylpyrimidine-2,4-diamine
  参考文献：
  名称：

  Triamino pyrimidines and pyridines as histamine H4 receptor modulators

  摘要：

  Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H-4 receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.017

文献信息

• Triamino pyrimidines and pyridines as histamine H4 receptor modulators
  作者：Steven P. Meduna、Brad M. Savall、Hui Cai、James P. Edwards、Robin L. Thurmond、Patricia M. McGovern

  DOI：10.1016/j.bmcl.2011.03.017

  日期：2011.5

  Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H-4 receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds. (C) 2011 Elsevier Ltd. All rights reserved.