1-chloro-2-methylheptane | 2350-16-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 1-chloro-2-methylheptane
• 英文别名: 1-chloro-2-methyl-heptane；1-Chlor-2-methyl-heptan；Heptane, 1-chloro-2-methyl
• CAS: 2350-16-5
• 化学式: C₈H₁₇Cl
• 分子量: 148.676
• InChiKey: BESCHJUENMYCOJ-UHFFFAOYSA-N

物化性质

• 保留指数：
  1019;1019

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-chloro-2-methylheptane 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 3.0h， 生成 5-methyldecanoic acid
  参考文献：
  名称：

  Do enzymes recognise remotely located stereocentres? Highly enantioselective Candida rugosa lipase-catalysed esterification of the 2- to 8-methyldecanoic acids

  摘要：

  Several racemic methyl decanoic acids have been synthesised and Successfully resolved in esterification with 1-hexadecanol at a(w)=0.8 in cyclohexane using immobilised Candida rugosa lipase (CRL) as the catalyst. The enantiomeric ratios (E=2.8-68) obtained were surprisingly high even when the methyl group was as remotely located as in 8-methyldecanoic acid (E=25). Interestingly, the lipase shows enantiopreference for the S-enantiomer when the methyl group is located on even numbered carbons i.e. for the 2-,4-,6- and 8-methyldecanoic acids and to the R-enantiomer when the methyl group is located on uneven numbered carbons i.e. for the 3-,5- and 7-methyldecanoic acids. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00172-6
• 作为产物：
  描述：

  2-甲基-1-庚醇 在 四氯化碳 、 三苯基膦 作用下， 反应 1.0h， 生成 1-chloro-2-methylheptane
  参考文献：
  名称：

  Do enzymes recognise remotely located stereocentres? Highly enantioselective Candida rugosa lipase-catalysed esterification of the 2- to 8-methyldecanoic acids

  摘要：

  Several racemic methyl decanoic acids have been synthesised and Successfully resolved in esterification with 1-hexadecanol at a(w)=0.8 in cyclohexane using immobilised Candida rugosa lipase (CRL) as the catalyst. The enantiomeric ratios (E=2.8-68) obtained were surprisingly high even when the methyl group was as remotely located as in 8-methyldecanoic acid (E=25). Interestingly, the lipase shows enantiopreference for the S-enantiomer when the methyl group is located on even numbered carbons i.e. for the 2-,4-,6- and 8-methyldecanoic acids and to the R-enantiomer when the methyl group is located on uneven numbered carbons i.e. for the 3-,5- and 7-methyldecanoic acids. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00172-6

文献信息

• Minimizing eluate band widths in liquid chromatography
  申请人：Hewlett-Packard Company

  公开号：EP0444441A2

  公开（公告）日：1991-09-04

  In accordance with the disclosed method (300), a surfactant (107) is mixed with a sample (105) prior to injection (303) onto a separation column so that both polar and nonpolar sample components can be enriched at the column head. The components are then separated (304) by reverse-phase gradient elution. The surfactant (107) permits nonpolar analytes to be dissolved in a solvent (e.g., water) which is sufficiently polar such that polar analytes are concentrated along with nonpolar analytes at the head (204) of the column. Thus, on-column enrichment is provided. The effects of the surfactant diminish during elution so that substantial separation of analytes is still obtained. As a result of the on-column enrichment, smaller-bore columns can be used. The smaller-bore columns provide for more concentrated peaks and thus greater detection sensitivity and quantitation accuracy.

  根据所公开的方法（300），在将表面活性剂（107）注入分离柱（303）之前，先与样品（105）混合，这样极性和非极性样品成分都能在柱头富集。然后通过反相梯度洗脱将这些成分分离出来（304）。表面活性剂（107）允许非极性分析物溶解在极性足够强的溶剂（如水）中，从而使极性分析物与非极性分析物一起富集在柱头（204）。这样就实现了柱上富集。表面活性剂的作用在洗脱过程中逐渐减弱，因此仍然可以获得大量的分析物分离。柱上富集的结果是可以使用较小孔径的色谱柱。较小孔径的色谱柱可提供更集中的峰值，从而提高检测灵敏度和定量准确性。
• 588. The synthesis and reactions of branched-chain hydrocarbons. Part XVII. N-chlorosulphonamides as chlorinating agents
  作者：A. E. Fuller、W. J. Hickinbottom

  DOI：10.1039/jr9650003228

  日期：——
• Phthalocyanine compounds and optical recording media comprising them
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0719839B1

  公开（公告）日：2001-07-25
• US5693396A
  申请人：——

  公开号：US5693396A

  公开（公告）日：1997-12-02