7-Bromo-8-chloro-3,4-dihydro-2H-benzo[1,4]oxazine-5-carboxylic acid | 123296-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-Bromo-8-chloro-3,4-dihydro-2H-benzo[1,4]oxazine-5-carboxylic acid
• 英文别名: 7-Bromo-8-chloro-3,4-dihydro-2H-1,4-benzoxazine-5-carboxylic acid
• CAS: 123296-73-1
• 化学式: C₉H₇BrClNO₃
• 分子量: 292.516
• InChiKey: QJLQIKCDLKVQMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-Bromo-9-chloro-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indole-5,6-dione 在 sodium hydroxide 、 双氧水 作用下， 生成 7-Bromo-8-chloro-3,4-dihydro-2H-benzo[1,4]oxazine-5-carboxylic acid
  参考文献：
  名称：

  Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

  摘要：

  A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00261-8

文献信息

• Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives
  作者：Yasushi Kohno、Katsuya Awano、Mitsutomo Miyashita、Shizuyoshi Fujimori、Kazuhiko Kuriyama、Yasuhiko Sakoe、Shinji Kudoh、Koji Saito、Eisuke Kojima

  DOI：10.1016/s0960-894x(97)00261-8

  日期：1997.6

  A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction. (C) 1997 Elsevier Science Ltd.