5-{4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-benzyl}-oxazolidine-2,4-dione | 132646-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-{4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-benzyl}-oxazolidine-2,4-dione
• 英文别名: 5-[[4-[2-(5-Methyl-2-naphthalen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,3-oxazolidine-2,4-dione
• CAS: 132646-53-8
• 化学式: C₂₆H₂₂N₂O₅
• 分子量: 442.471
• InChiKey: ORAKYKWVSZVLTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  90.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-naphthalen-2-yl-oxazole 在 methyl magnesium carbonate 、 三氟乙酸 作用下， 反应 4.0h， 生成 5-{4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-benzyl}-oxazolidine-2,4-dione
  参考文献：
  名称：

  Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

  摘要：

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

  DOI：

  10.1021/jm00109a003

文献信息

• Oxazolidinedione hypoglycemic agents
  申请人：PFIZER INC.

  公开号：EP0428312B1

  公开（公告）日：1994-12-28
• DOW, ROBERT L.;BECHLE, BRUCE M.;CHOU, THOMAS T.;CLARK, DAVID A.;HULIN, BE+, J. MED. CHEM., 34,(1991) N, C. 1538-1544
  作者：DOW, ROBERT L.、BECHLE, BRUCE M.、CHOU, THOMAS T.、CLARK, DAVID A.、HULIN, BE+

  DOI：——

  日期：——
• US5498621A
  申请人：——

  公开号：US5498621A

  公开（公告）日：1996-03-12
• [EN] OXAZOLIDINEDIONE HYPOGLYCEMIC AGENTS
  申请人：——

  公开号：WO1991007107A1

  公开（公告）日：1991-05-30

  [EN] Compounds of fomulae (I) and (II), where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH, are useful as hypoglycemic agents.
  [FR] Composés de formules (I) et (II), dans lesquelles R représente cycloalkyle ou aryle; R1 représente alkyle, X représente O ou C=O; A représente O ou S; et B représente N ou CH. Ces composés sont utiles en tant qu'agents hypoglycémiques.
• Benzyloxazolidine-2,4-diones as potent hypoglycemic agents
  作者：Robert L. Dow、Bruce M. Bechle、Thomas T. Chou、David A. Clark、Bernard Hulin、Ralph W. Stevenson

  DOI：10.1021/jm00109a003

  日期：1991.5

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.