2-amino-5,6-dichloro-3,4-dihydro-1(2H)-naphthalenone | 750544-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-amino-5,6-dichloro-3,4-dihydro-1(2H)-naphthalenone
• 英文别名: 2-amino-5,6-dichloro-3,4-dihydro-2H-naphthalen-1-one
• CAS: 750544-12-8
• 化学式: C₁₀H₉Cl₂NO
• 分子量: 230.094
• InChiKey: RDYLPQSBUKTYDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-5,6-dichloro-3,4-dihydro-1(2H)-naphthalenone 在 sodium tetrahydroborate 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 5.33h， 生成 trans-2-(isopropylamino)-5,6-dichloro-1,2,3,4-tetrahydronaphthalen-1-ol
  参考文献：
  名称：

  Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

  摘要：

  The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.

  DOI：

  10.1016/0223-5234(93)90034-c
• 作为产物：
  描述：

  5,6-dichloro-3,4-dihydronaphthalen-1(2H)-one O-p-toluensulfonyl oxime 在 potassium ethoxide 作用下， 以 苯 为溶剂， 生成 2-amino-5,6-dichloro-3,4-dihydro-1(2H)-naphthalenone
  参考文献：
  名称：

  Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

  摘要：

  The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.

  DOI：

  10.1016/0223-5234(93)90034-c

文献信息

• Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol
  作者：A Balsamo、MC Breschi、G Giannaccini、A Lapucci、A Lucacchini、B Macchia、C Manera、C Martini、E Martinotti、S Nencetti、A Rossello、R Scatizzi

  DOI：10.1016/0223-5234(93)90034-c

  日期：1993.1

  The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity.