butyl 3-(4-methylpiperazin-1-yl)propanoate | 1030613-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: butyl 3-(4-methylpiperazin-1-yl)propanoate
• 英文别名: Butyl 4-methyl-1-piperazinepropanoate
• CAS: 1030613-28-5
• 化学式: C₁₂H₂₄N₂O₂
• 分子量: 228.335
• InChiKey: WKFHCRQWPMEQJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 丙烯酸丁酯 在 CLEA Pseudomonas stutzeri lipase (PSL) 作用下， 以 正己烷 为溶剂， 反应 96.0h， 以95%的产率得到butyl 3-(4-methylpiperazin-1-yl)propanoate
  参考文献：
  名称：

  Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives

  摘要：

  A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas viscosum lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations.

  DOI：

  10.1021/jo400268u

文献信息

• MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20180221279A1

  公开（公告）日：2018-08-09

  Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a LN transmembrane pH or ion gradient into the aqueous interior of the LN. The weak-base moiety can optionally comprise a lipophilic domain that facilitates active loading of the drag to the inner monolayer of the liposomal membrane. Advantageously, LN formulations of the drag derivatives exhibit improved solubility, reduced toxicity, enhanced efficacy, and/or other benefits relative to the corresponding free drags.

  本文提供了适用于装载到脂质体纳米粒载体中的药物衍生物。在一些首选方面，这些衍生物包括一种水溶性较差的药物衍生物，其与一种弱碱基团衍生化，有助于通过LN跨膜pH或离子梯度将药物活性地装载到LN的水相内部。弱碱基团可以选择性地包括一个亲脂性结构域，有助于将药物活性地装载到脂质体膜的内单分子层。优点是，药物衍生物的LN配方相对于相应的游离药物表现出改善的溶解度、降低的毒性、增强的疗效和/或其他优点。
• Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives
  作者：Peter Steunenberg、Maarten Sijm、Han Zuilhof、Johan P. M. Sanders、Elinor L. Scott、Maurice C. R. Franssen

  DOI：10.1021/jo400268u

  日期：2013.4.19

  A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas viscosum lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations.
• US7625886B2
  申请人：——

  公开号：US7625886B2

  公开（公告）日：2009-12-01
• US9968554B2
  申请人：——

  公开号：US9968554B2

  公开（公告）日：2018-05-15
• Efficient and reusable ionic liquid stabilized magnetic cobalt nanoparticles as catalysts for aza- and thia-Michael reactions
  作者：Manika Dewan、Arnab De、Subho Mozumdar

  DOI：10.1016/j.inoche.2015.01.027

  日期：2015.3