1,4-Dihydroxy-2-furfuryl-benzol | 91344-69-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1,4-Dihydroxy-2-furfuryl-benzol
• 英文别名: 2-<2,5-Dihydro-benzyl>-furan；2-(2-furanylmethyl)hydroquinone；2-furfuryl-benzene-1,4-diol；2-furfurylhydroquinone；2-(furan-2-ylmethyl)benzene-1,4-diol
• CAS: 91344-69-3
• 化学式: C₁₁H₁₀O₃
• 分子量: 190.199
• InChiKey: XILYZMFMZQXKMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-Dihydroxy-2-furfuryl-benzol 、 4-(6-acryloylhex-1-yloxy)benzoic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以47%的产率得到4-(6-acryloyloxyhexyloxy)benzoic acid 4-[4-(6-acryloyloxyhexyloxy)benzoyloxy]3-furan-2-ylmethylphenyl ester
  参考文献：
  名称：

  LIQUID CRYSTAL COMPOUNDS

  摘要：

  公开号：

  EP1154981B1
• 作为产物：
  描述：

  糠醛 、 1,4-环己二酮 在 lithium chloride 作用下， 以 various solvent(s) 为溶剂， 反应 1.0h， 以96%的产率得到1,4-Dihydroxy-2-furfuryl-benzol
  参考文献：
  名称：

  A Convenient Synthesis of 2-Alkylated 1,4-Benzenediols

  摘要：

  在金属卤化物的存在下，1,4-环己二酮与多种醛反应，以良好的产率生成了2-烷基化的1,4-苯二酚，没有任何芳香副产物。

  DOI：

  10.1055/s-1997-806

文献信息

• Laterally substituted curable liquid crystals
  申请人：Rolic AG

  公开号：US06676851B1

  公开（公告）日：2004-01-13

  In one embodiment, the invention relates to compounds of the formula (I) wherein G1 and G2 independently represent a polymerizable mesogenic residue, and X, Sp, and Q are as defined herein. The compounds of the invention may, for example, be useful as curable liquid crystals and for preparing liquid crystal films.

  在一种实施例中，本发明涉及公式（I）中的化合物，其中G1和G2分别表示可聚合的介向残基，而X、Sp和Q如本文所定义。本发明的化合物可以作为可固化的液晶和制备液晶薄膜的有用材料。
• Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase
  作者：Stefan Paula、Josh Abell、Joel Deye、Christopher Elam、Michael Lape、Justin Purnell、Robert Ratliff、Kelly Sebastian、Jodie Zultowsky、Robert J. Kempton

  DOI：10.1016/j.bmc.2009.07.075

  日期：2009.9

  Analogues of the compound 2,5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal value as agents against prostate cancer. This study describes the synthesis of 13 compounds representing several classes of BHQ analogues, such as hydroquinones with a single aromatic substituent, symmetrically and unsymmetrically disubstituted hydroquinones, and hydroquinones with x-amino acid tethers attached to their hydroxyl groups. Structure-activity relationships were established by measuring the inhibitory potencies of all synthesized compounds in bioassays. The assays were complemented by computational ligand docking for an analysis of the relevant ligand/receptor interactions. (C) 2009 Elsevier Ltd. All rights reserved.
• US6676851B1
  申请人：——

  公开号：US6676851B1

  公开（公告）日：2004-01-13
• [EN] LIQUID CRYSTAL COMPOUNDS<br/>[FR] COMPOSES DE CRISTAUX LIQUIDES
  申请人：ROLIC AG

  公开号：WO2000048985A1

  公开（公告）日：2000-08-24

  A compound of formula (I), wherein G?1 and G2¿ independently represent a polymerisable mesogenic residue X represents a group selected from the group consisting -CH¿2?-, -O-, -CO-, -COO-, -OOC-, -CONR'-, -OCOO- and -OCONR'; Sp represents a group of the formula -(CH2)p- in which p is an integer of 1 to 18 and in which one or two non adjacent -CH2- groups are optionally replaced by -CH=CH-; or in which one or two -CH2- groups may be replaced by one or two groups selected from the group consisting -CH2-, -O-, -CO-, -COO-, -OOC-, -CONR'-, -OCOO- and -OCONR'- with the proviso that firstly the spacer group does not contain two adjacent heteroatoms and secondly when X is -CH2-, p can also have a value of 0; Q represents a a polar group selected from -CN, -COR, -COOR, -OCOR, -CONR'R, -NR'COR, -OCOOR, -OCONR'R, -NR'COOR, F, Cl, -CF3, -OCF3 or -OR or a cyclic group which is unsubstituted or optionally substituted by a group selected from a lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, halogen, -CN, -COR'', -COOR'', -OCOR'', -CONR'R'', -NR'COR'', -OCOOR'', -OCONR'R'', -NR'COOR'', -CF3, and -OCF3; where R represents hydrogen, a lower alkyl, a lower alkenyl or a cyclic group as defined above; and R' is hydrogen, a lower alkyl or a lower alkenyl group; R'' represents a lower alkyl or a lower alkenyl group and liquid crystal mixtures containing the compounds.