2-[4,5-dioxo-2-(4-tolyl)-4,5-dihydro-3-furyl]-3-(4-tolyl)quinoxaline | 308086-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[4,5-dioxo-2-(4-tolyl)-4,5-dihydro-3-furyl]-3-(4-tolyl)quinoxaline
• 英文别名: 2-(4,5-dioxo-2-p-tolyl-4,5-dihydro-3-furyl)-3-p-tolylquinoxaline；5-(4-methylphenyl)-4-[3-(4-methylphenyl)quinoxalin-2-yl]-2,3-dihydrofuran-2,3-dione；5-(4-Methylphenyl)-4-[3-(4-methyl-phenyl)quinoxalin-2-yl]-2,3-dihydrofuran-2,3-dione；5-(4-methylphenyl)-4-[3-(4-methylphenyl)quinoxalin-2-yl]furan-2,3-dione
• CAS: 308086-65-9
• 化学式: C₂₆H₁₈N₂O₃
• 分子量: 406.441
• InChiKey: XSZBTGZXFSHOQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  612.6±65.0 °C(Predicted)
• 密度：
  1.316±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  69.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[4,5-dioxo-2-(4-tolyl)-4,5-dihydro-3-furyl]-3-(4-tolyl)quinoxaline 以 xylene 为溶剂， 反应 0.33h， 以74%的产率得到5-p-tolyl-2-(3-p-tolyl-2-quinoxalinyl)-4-p-toluoyl-3-p-toluoyloxy-1H-pyrido[1,2-a]quinoxalin-1-one
  参考文献：
  名称：

  10.1023/a:1013886602711

  摘要：

  DOI：

  10.1023/a:1013886602711
• 作为产物：
  描述：

  草酰氯 、 1-(4-methylphenyl)-2-[3-(4-methylphenyl)quinoxalin-2(1H)-ylidene]ethanone 以 氯仿 为溶剂， 以90%的产率得到2-[4,5-dioxo-2-(4-tolyl)-4,5-dihydro-3-furyl]-3-(4-tolyl)quinoxaline
  参考文献：
  名称：

  摘要：

  3-Aryl-Z-2-aroylmethylidene-1,2-dihydroquinoxalines react with oxalyl chloride to form 3-aryl-2-(2-aryl-4,5-dioxo-4,5-dihydro-3-furyl)quinoxalines, whose thermal decarbonylation generate 5-aryl-2-3(arylquinoxalin-2-yl)-4-aroyl-3-aroyloxy-1H-pyrido[1,2-a]quinoxalin-1-ones. The crystal and molecular structures of one of them (Ar = Ph) were established by X-ray diffraction analysis.

  DOI：

  10.1023/a:1016097120253

文献信息

• Synthesis of stable 1,4-diionic organophosphorus compounds from the reaction between triphenylphosphine and diaroylacetylenes in the presence of 5-aryl-4-quinoxalin-2-yl-furan-2,3-diones
  作者：Natalya Yu. Lisovenko、Artem V. Dryahlov、Maxsim V. Dmitriev

  DOI：10.1080/10426507.2017.1295962

  日期：2017.8.3

  GRAPHICAL ABSTRACT ABSTRACT Novel 1,4-diionic organophosphorus compounds have been obtained efficiently from the one-pot three-component reaction of triphenylphosphine, diaroylacetylenes and 5-aryl-4-quinoxalin-2-yl-furan-2,3-diones in 1,2-dichloroethane. The synthesized compounds were characterized by different spectroscopic methods and their structure was confirmed in one case by single crystal X-ray

  图形摘要 摘要 从三苯基膦、二芳酰基乙炔和 5-芳基-4-喹喔啉-2-基-呋喃-2,3-二酮在 1 中的一锅三组分反应中有效地获得了新型 1,4-二离子有机磷化合物。 ,2-二氯乙烷。合成的化合物通过不同的光谱方法进行了表征，并且在一种情况下通过单晶 X 射线衍射证实了它们的结构。
• Three-component reaction of 5-aryl-4-(quinoxalin-2-yl)-furan-2,3-diones, acetylenedicarboxylic acid dimethyl ester, and triphenylphosphine
  作者：N. Yu. Lisovenko、A. V. Dryahlov、M. V. Dmitriev

  DOI：10.1134/s1070428016080157

  日期：2016.8

  Three-component synthesis from 5-aryl-4-(quinoxalin-2-yl)furan-2,3-diones, acetylenedicarboxylic acid dimethyl ester, and triphenylphosphine afforded methyl esters of 1,6-dioxaspiro[4.4]nona-3,7-diene-4-carboxylic and 4H-furo[3,2-c]pyran-3-carboxylic acids.

  由5-芳基-4-（喹喔啉-2-基）呋喃-2,3-二酮，乙炔二羧酸二甲酯和三苯膦三组分合成，得到1,6-二氧杂螺[4.4] nona-3,7的甲酯-二烯-4-羧酸和4 H-呋喃[3,2 - c ]吡喃-3-羧酸。
• Thermolytic transformations of 5-aryl-4-quinoxalin-2-ylfuran-2,3-diones in the presence of n-cyano compounds
  作者：N. Yu. Lisovenko、D. D. Nekrasov、V. I. Karmanov

  DOI：10.1007/s10593-012-1144-6

  日期：2012.12

  6-Aryl-5-quinoxalinyl-1,3-oxazin-4-ones were obtained by thermolysis of 5-aryl-4-quinoxalinylfuran-2,3-diones in the presence of tert-butylcyanamide, 4-morpholinecarbonitrile, and N-cyanobenzamide.
• Regioselective Cycloaddition of Azomethines and Carbodiimides to Aroyl(quinoxalinyl)ketenes
  作者：N. Yu. Lisovenko、A. N. Maslivets

  DOI：10.1023/b:cohc.0000027901.78882.86

  日期：2004.2
• Chemistry of iminofurans. New example of unusual aza-Wittig reaction at lactone carbonyl group
  作者：N. Yu. Lisovenko、A. E. Rubtsov

  DOI：10.1134/s1070428010060291

  日期：2010.6