4-amino-1-methyl-6-methylthio-1H-pyrazolo<3,4-d>pyrimidine | 130819-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 4-amino-1-methyl-6-methylthio-1H-pyrazolo<3,4-d>pyrimidine
• 英文别名: 1-Methyl-6-methylsulfanylpyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 130819-82-8
• 化学式: C₇H₉N₅S
• 分子量: 195.248
• InChiKey: DUAHJNJLYCQMBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  94.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-methyl-4,6-dimethylthiopyrazolo[3,4-d]pyrimidine 在 氨 作用下， 以 甲醇 为溶剂， 以75%的产率得到4-amino-1-methyl-6-methylthio-1H-pyrazolo<3,4-d>pyrimidine
  参考文献：
  名称：

  Garg; Avasthi; Pratap, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1990, vol. 29, # 9, p. 859 - 864

  摘要：

  DOI：

文献信息

• [EN] NEW PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF GRAM-NEGATIVE BACTERIAL INFECTION, CONTAMINATION AND FOULING<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIMIDINE POUR LA PRÉVENTION ET LE TRAITEMENT D'UNE INFECTION, D'UNE CONTAMINATION ET DE SALISSURES PAR UNE BACTÉRIE À GRAM NÉGATIF
  申请人：UNIV LIEGE

  公开号：WO2020212553A1

  公开（公告）日：2020-10-22

  New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.

  新的嘧啶衍生物与膜穿透剂一起，可选地带有可检测同位素和药物组合物，用于治疗或预防宿主哺乳动物体内需要此类治疗或预防的革兰氏阴性细菌感染，并用作抑制生物材料或医疗器械表面上的革兰氏阴性生物膜形成的抑制剂，特别是心血管器械，如假体心脏瓣膜或起搏器。新的嘧啶衍生物与膜穿透剂一起；用作放射示踪剂，用于诊断或预测宿主哺乳动物体内的革兰氏阴性细菌感染。
• GARG, NEERAJ;AVASTHI, K.;PRATAP, RAM;BHAKUNI, D. S.;GURU, P. Y., INDIAN J. CHEM. B, 29,(1990) N, C. 859-864
  作者：GARG, NEERAJ、AVASTHI, K.、PRATAP, RAM、BHAKUNI, D. S.、GURU, P. Y.

  DOI：——

  日期：——
• [EN] PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] DÉRIVÉS DE PYRIMIDINE POUR PRÉVENIR ET TRAITER DES INFECTIONS BACTÉRIENNES
  申请人：UNIV LIEGE

  公开号：WO2019158655A1

  公开（公告）日：2019-08-22

  New pyrimidine derivatives of formula (I), optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. New pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.
• Garg; Avasthi; Pratap, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1990, vol. 29, # 9, p. 859 - 864
  作者：Garg、Avasthi、Pratap、Bhakuni、Guru

  DOI：——

  日期：——